Department of Forensic Medicine, Nicolaus Copernicus University Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland.
Faculty of Telecommunications, Computer Science and Electrical Engineering, Bydgoszcz University of Science and Technology, Bydgoszcz, Poland.
PLoS One. 2022 Dec 27;17(12):e0279573. doi: 10.1371/journal.pone.0279573. eCollection 2022.
A queueing theory based model of mTOR complexes impact on Akt-mediated cell response to insulin is presented in this paper. The model includes several aspects including the effect of insulin on the transport of glucose from the blood into the adipocytes with the participation of GLUT4, and the role of the GAPDH enzyme as a regulator of mTORC1 activity. A genetic algorithm was used to optimize the model parameters. It can be observed that mTORC1 activity is related to the amount of GLUT4 involved in glucose transport. The results show the relationship between the amount of GAPDH in the cell and mTORC1 activity. Moreover, obtained results suggest that mTORC1 inhibitors may be an effective agent in the fight against type 2 diabetes. However, these results are based on theoretical knowledge and appropriate experimental tests should be performed before making firm conclusions.
本文提出了一种基于排队论的 mTOR 复合物对胰岛素介导的细胞反应的影响模型。该模型包括几个方面，包括胰岛素对葡萄糖从血液向脂肪细胞运输的影响，以及 GAPDH 酶作为 mTORC1 活性调节剂的作用。遗传算法被用于优化模型参数。可以观察到，mTORC1 活性与参与葡萄糖运输的 GLUT4 数量有关。结果表明了细胞内 GAPDH 的数量与 mTORC1 活性之间的关系。此外，研究结果表明，mTORC1 抑制剂可能是对抗 2 型糖尿病的有效药物。然而，这些结果是基于理论知识得出的，在得出确定的结论之前，应该进行适当的实验测试。
