Poverennyĭ A M, Riabchenko N I
Med Radiol (Mosk). 1987 Sep;32(9):31-4.
An analysis of the data on the effect of lymphoid cells on the proliferation and differentiation of hemopoietic stem cells has led to a conclusion that radiation injury of lymphocytes plays an important role in the pathogenesis of the cerebrospinal syndrome. The molecular mechanisms of lymphocyte interphase death were considered. It was shown that due to some peculiarities in the energy supply of these cells the appearance of breaks in DNA causes the development of biochemical processes resulting in a decrease in NAD, an increase in the activity of nucleases, a decrease in ATP, and the accumulation of active metabolites of glycolysis. These reactions result in an increase in the disintegration of DNA, chromatin and pyknosis of lymphocyte nuclei.
淋巴细胞的辐射损伤在脑脊髓综合征的发病机制中起重要作用。研究了淋巴细胞间期死亡的分子机制。结果表明，由于这些细胞能量供应的某些特点，DNA断裂的出现会引发生化过程，导致NAD减少、核酸酶活性增加、ATP减少以及糖酵解活性代谢产物的积累。这些反应导致DNA分解增加、染色质变化以及淋巴细胞核固缩。
