Garcia Garcia Cristobal, Patkar Sai S, Wang Bin, Abouomar Ramadan, Kiick Kristi L
Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.
Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA; Department of Biomedical Engineering, University of Delaware, Newark, DE 19176, USA.
Adv Drug Deliv Rev. 2023 Feb;193:114673. doi: 10.1016/j.addr.2022.114673. Epub 2022 Dec 24.
Injectable nanocarriers and hydrogels have found widespread use in a variety of biomedical applications such as local and sustained biotherapeutic cargo delivery, and as cell-instructive matrices for tissue engineering. Recent advances in the development and application of recombinant protein-based materials as injectable platforms under physiological conditions have made them useful platforms for the development of nanoparticles and tissue engineering matrices, which are reviewed in this work. Protein-engineered biomaterials are highly customizable, and they provide distinctly tunable rheological properties, encapsulation efficiencies, and delivery profiles. In particular, the key advantages of emerging technologies which harness the stimuli-responsive properties of recombinant polypeptide-based materials are highlighted in this review.
可注射纳米载体和水凝胶已在多种生物医学应用中得到广泛应用，如局部和持续生物治疗药物递送，以及作为组织工程的细胞诱导基质。在生理条件下，基于重组蛋白的材料作为可注射平台的开发和应用的最新进展使其成为开发纳米颗粒和组织工程基质的有用平台，本文对此进行综述。蛋白质工程生物材料具有高度的可定制性，它们提供了明显可调节的流变学特性、封装效率和递送特性。特别是，本综述强调了利用基于重组多肽的材料的刺激响应特性的新兴技术的关键优势。
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