Department of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, 61186, Republic of Korea.
Department of Oral Medicine, School of Dentistry, Chonnam National University, Gwangju, 61186, Republic of Korea.
Int J Nanomedicine. 2022 Dec 21;17:6551-6560. doi: 10.2147/IJN.S382053. eCollection 2022.
Mid-to-long term use of provisional crowns in the oral cavity is associated with bacterial adhesion and biofilm formation, thus necessitating provisional crowns exhibiting antibacterial properties to prevent the occurrence of gingivitis and periodontal disease. This study aimed to evaluate the antibacterial effect of zirconia nanoparticle-containing polyethyl methacrylate (PEMA) resin for provisional restorations.
Zirconia nanoparticles were added to the monomer of PEMA resin for provisional restorations, and the mixture was stirred for 2 h using a magnetic stirrer. Disk-shaped specimens were prepared by mixing the polymer with the nanoparticle solution. The control group contained pure PEMA resin samples, and the experimental groups Group Z2, Group Z4, and Group Z8 included PEMA resin specimens containing 2, 4, and 8% w/v zirconia nanoparticles, respectively. After analyzing the sample surfaces, the antibacterial effect of the specimens was evaluated using . Statistical analysis was performed using Tukey's test and Mann-Whitney -test, according to the normality result in the Shapiro-Wilk test.
FE-SEM and EDX analyses revealed the successful addition of zirconia nanoparticles. Results showed no significant difference in the measured values for surface roughness and contact angle between the experimental and control groups; however, adhesion and biofilm thickness of were significantly decreased in Group Z2, Group Z4, and Group Z8 compared to the control group ( < 0.05, < 0.01, < 0.01, respectively).
The addition of zirconia nanoparticles can lower the incidence of adhesion and biofilm thickness of on PEMA resin used for provisional crowns. Thus, incorporating zirconia nanoparticles in repair materials for provisional crowns and PEMA resin can produce an antibacterial effect and prevent gingivitis, periodontal disease, and dental caries.
口腔内临时冠的中长期使用会导致细菌黏附及生物膜形成，因此需要具有抗菌性能的临时冠来预防牙龈炎和牙周病的发生。本研究旨在评估载氧化锆纳米颗粒的聚甲基丙烯酸乙酯（PEMA）树脂用于临时修复体的抗菌效果。
将氧化锆纳米颗粒添加到 PEMA 树脂的单体中，使用磁力搅拌器搅拌 2 h。通过将聚合物与纳米颗粒溶液混合制备出圆盘状试件。对照组为纯 PEMA 树脂样品，实验组分别为包含 2% w/v、4% w/v 和 8% w/v 氧化锆纳米颗粒的实验组 Z2、实验组 Z4 和实验组 Z8。分析样品表面后，使用 评估试件的抗菌效果。根据 Shapiro-Wilk 检验的正态性结果，使用 Tukey 检验和 Mann-Whitney -检验进行统计分析。
FE-SEM 和 EDX 分析表明成功添加了氧化锆纳米颗粒。结果显示，实验组和对照组的表面粗糙度和接触角测量值之间没有显著差异；然而，与对照组相比，实验组 Z2、实验组 Z4 和实验组 Z8 中 黏附力和生物膜厚度显著降低（<0.05，<0.01，<0.01，分别）。
添加氧化锆纳米颗粒可以降低 PEMA 树脂临时冠上 的黏附力和生物膜厚度。因此，在临时冠修复材料和 PEMA 树脂中加入氧化锆纳米颗粒可以产生抗菌效果，预防牙龈炎、牙周病和龋齿。
