细菌产物在牙周炎中的作用：对啮蚀艾肯菌的体液免疫反应。
Role of bacterial products in periodontitis: humoral immune response to Eikenella corrodens.
作者信息
Johnson D A, Behling U H, Listgarten M, Nowotny A
出版信息
Infect Immun. 1978 Nov;22(2):382-6. doi: 10.1128/iai.22.2.382-386.1978.
Abstract
Eikenella corrodens can induce periodontitis-like disease in gnotobiotic rats. Some components of this bacterial cell elicit measurable humoral immune response during the development of the disease, but in this system endotoxin is not among the efficient immunogens. Because no humoral immune response could be seen to the endotoxin of Eikenella corrodens it is assumed that this endotoxin can act uncontrolled in monoinfected rats. Accordingly, the lack of protective humoral immune response to pathogenic components of Eikenella corrodens may be the major factor permitting the development of the disease described here. The possibility that both cell-mediated immunity and uncontrolled endotoxic action are parts of the pathomechanism of the disease is supported by our observations.
摘要
啮蚀艾肯菌可在无菌大鼠中诱发类牙周炎疾病。在疾病发展过程中，这种细菌细胞的某些成分会引发可测量的体液免疫反应，但在该系统中，内毒素并非有效的免疫原。由于未观察到针对啮蚀艾肯菌内毒素的体液免疫反应，因此推测这种内毒素在单感染大鼠中可能不受控制地发挥作用。因此，对啮蚀艾肯菌致病成分缺乏保护性体液免疫反应可能是导致此处所述疾病发展的主要因素。我们的观察结果支持细胞介导的免疫和不受控制的内毒素作用都是该疾病发病机制一部分的可能性。
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