Behling U H, Sallay C, Sanavi F, Pham P H, Nowotny A
Infect Immun. 1981 Sep;33(3):801-5. doi: 10.1128/iai.33.3.801-805.1981.
Germfree Sprague-Dawley rats monoassociated with Eikenella corrodens exhibited alveolar bone loss. This progressive bone loss occurred over a period of weeks, during which time the hosts developed an immune response toward the infective microorganism. By means of repeated bacterial vaccination resulting in elevated serum antibody titers, reduced bone loss was observed.
与腐蚀艾肯菌单关联的无菌斯普拉格-道利大鼠出现了牙槽骨丢失。这种渐进性骨丢失在数周内发生,在此期间宿主对感染微生物产生了免疫反应。通过反复细菌疫苗接种导致血清抗体滴度升高,观察到骨丢失减少。