Proteus dysbioses in patients with ulcerative colitis.

In patients with ulcerative colitis Proteus could be isolated from all the gastrointestinal portions studied: mouth cavity, stomach, small intestine, small intestinal mucous membrane, and mostly from faeces. In some patients with ulcerative colitis a decrease in membraneous hydrolysis of polysaccharides was noted. Severe Proteus dysbiosis was associated with a sharp decrease in absorption processes at the small intestinal mucous membrane. The Proteus strains obtained from the patients belonged mostly to 3 serogroups: OA, OB, OC. Studies in virulent properties of Proteus in experiments with white mice gave positive results in 96% cases. Enterotoxin could be found in no case. As the result of vaccinal therapy in most patients disappearance or decrease of signs of malabsorption, increase in weight, stool normalization, and better hematological indices was manifested.