用于促进疾病缓解的疗法,针对患有活动性疾病的溃疡性结肠炎患者的肠道菌群失调。

Therapy Used to Promote Disease Remission Targeting Gut Dysbiosis, in UC Patients with Active Disease.

作者信息

Mirsepasi-Lauridsen Hengameh Chloè

机构信息

1Health Gut Inn Balance APS, Kloevermarken 7, 2680 Solroed Strand, Denmark.

出版信息

J Clin Med. 2022 Dec 16;11(24):7472. doi: 10.3390/jcm11247472.

Abstract

Ulcerative colitis (UC) is a relapsing non-transmural chronic inflammatory disease of the colon characterized by bloody diarrhea. The etiology of UC is unknown. The goal is to reduce the inflammation and induce disease remission in UC patients with active disease. The aim of this study is to investigate the innovative treatment method used to promote disease remission in UC patients with active disease targeting gut dysbiosis. Immunosuppressants such as TNF-α blocker are used to promote disease remission in UC, but it is expensive and with side effects. Probiotic, prebiotic and diet are shown to be effective in maintaining disease remission. Fecal microbiota transplantation (FMT) might be the future therapy option to promote disease remission in UC patients with active disease. However, correct manufacturing and administration of the FMT are essential to achieve successful outcome. A few cohorts with FMT capsules show promising results in UC patients with active disease. However, randomized controlled clinical trials with long-term treatment and follow-up periods are necessary to show FMT capsules' efficacy to promote disease remission in UC patients.

摘要

溃疡性结肠炎(UC)是一种以血性腹泻为特征的复发性非透壁性结肠慢性炎症性疾病。UC的病因尚不清楚。目标是减轻炎症并诱导活动性疾病的UC患者病情缓解。本研究的目的是调查用于促进活动性疾病的UC患者病情缓解的创新治疗方法,该方法针对肠道菌群失调。诸如TNF-α阻滞剂等免疫抑制剂用于促进UC患者病情缓解,但费用昂贵且有副作用。益生菌、益生元和饮食已被证明在维持病情缓解方面有效。粪便微生物群移植(FMT)可能是促进活动性疾病的UC患者病情缓解的未来治疗选择。然而,正确制备和施用FMT对于取得成功结果至关重要。一些使用FMT胶囊的队列研究在活动性疾病的UC患者中显示出有希望的结果。然而,需要进行长期治疗和随访期的随机对照临床试验,以证明FMT胶囊在促进UC患者病情缓解方面的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f0/9784819/371c278a6710/jcm-11-07472-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索