Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Front Cell Infect Microbiol. 2022 Dec 12;12:1063291. doi: 10.3389/fcimb.2022.1063291. eCollection 2022.
Leishmaniasis presents different types of clinical manifestations that can be divided into cutaneous leishmaniasis and visceral leishmaniasis. The host's immune system, associated with genetic and nutritional factors, is strongly involved in the evolution of the disease or parasite escape. Humoral immunity is characterized by the production of antibodies capable of promoting neutralization, opsonization, and activation of the complement system. In this scenario, B lymphocytes produce antibodies that play an important role in Leishmania infection although neglected for a long time. Thus, relevant aspects in the establishment of Leishmania infection will be addressed, highlighting the importance of humoral immunity during the entire process of Leishmania infection.
利什曼病呈现出不同类型的临床表现，可分为皮肤利什曼病和内脏利什曼病。宿主的免疫系统与遗传和营养因素有关，它强烈参与疾病的演变或寄生虫的逃逸。体液免疫的特征是产生能够促进中和、调理和激活补体系统的抗体。在这种情况下，B 淋巴细胞产生抗体，尽管长期以来被忽视，但在利什曼虫感染中起着重要作用。因此，本文将探讨利什曼虫感染建立过程中的相关方面，强调体液免疫在整个利什曼虫感染过程中的重要性。
