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J Med Virol. 2023 Jan;95(1):e28443. doi: 10.1002/jmv.28443.
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Real-world effectiveness and safety of nirmatrelvir-ritonavir (Paxlovid)-treated for COVID-19 patients with onset of more than 5 days: a retrospective cohort study.奈玛特韦-利托那韦（帕罗韦德）治疗发病超过5天的COVID-19患者的真实世界有效性和安全性：一项回顾性队列研究。
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A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation.核酸与新冠病毒N蛋白的比例狭窄会导致相分离。
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本文引用的文献

1
Paxlovid in patients who are immunocompromised and hospitalised with SARS-CoV-2 infection.用于免疫功能低下且因感染新型冠状病毒而住院的患者的帕罗韦德。
Lancet Infect Dis. 2022 Sep;22(9):1279. doi: 10.1016/S1473-3099(22)00430-3. Epub 2022 Jul 14.
2
Hospitalization and Emergency Department Encounters for COVID-19 After Paxlovid Treatment - California, December 2021-May 2022.加利福尼亚州 2021 年 12 月至 2022 年 5 月辉瑞公司新冠口服药 Paxlovid 治疗后因 COVID-19 住院和急诊就诊情况。
MMWR Morb Mortal Wkly Rep. 2022 Jun 24;71(25):830-833. doi: 10.15585/mmwr.mm7125e2.
3
Effectiveness of Paxlovid in Reducing Severe Coronavirus Disease 2019 and Mortality in High-Risk Patients.帕克洛维德降低高危患者的严重 2019 冠状病毒病和死亡率的有效性。
Clin Infect Dis. 2023 Feb 8;76(3):e342-e349. doi: 10.1093/cid/ciac443.
4
Nirmatrelvir Plus Ritonavir: First Approval.奈玛特韦片/利托那韦片：首次获批。
Drugs. 2022 Apr;82(5):585-591. doi: 10.1007/s40265-022-01692-5.
5
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19.奈玛特韦片/利托那韦片组合包装口服药用于伴有进展为重症高风险因素的 COVID-19 门诊患者。
N Engl J Med. 2022 Apr 14;386(15):1397-1408. doi: 10.1056/NEJMoa2118542. Epub 2022 Feb 16.

Early administration of Paxlovid reduces the viral elimination time in patients infected with SARS-CoV-2 Omicron variants.

作者信息

Wang Yu, Zhao Danyang, Liu Xinbing, Chen Xubo, Xiao Wenying, Feng Liuliu

机构信息

Department of Cardiology, Shidong Hospital, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

J Med Virol. 2023 Jan;95(1):e28443. doi: 10.1002/jmv.28443.

DOI:10.1002/jmv.28443
PMID:36579782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9880690/
Abstract
摘要