Wang Yuchen, Li Tao
Department of Pediatrics, Affiliated Taihe Hospital of Hubei University of Medicine Shiyan Hubei China.
Pediatr Investig. 2022 Aug 1;6(4):271-279. doi: 10.1002/ped4.12341. eCollection 2022 Dec.
Kawasaki disease (KD) is a systemic vasculitis of unknown etiology, which tends to involve coronary arteries and can lead to acquired heart disease in children. The immuno-inflammatory response and vascular endothelial dysfunction are important causes of coronary artery disease in patients with KD. Multisystem inflammatory syndrome in children (MIS-C) is a rare inflammatory disease in children identified in recent years, which is caused by severe acute respiratory syndrome coronavirus 2 infection; this disease overlaps with KD. This review examines research progress concerning the immuno-inflammatory response and vascular endothelial dysfunction associated with KD, as well as differences between KD and MIS-C.
川崎病（KD）是一种病因不明的全身性血管炎，易累及冠状动脉，可导致儿童获得性心脏病。免疫炎症反应和血管内皮功能障碍是KD患者冠状动脉疾病的重要病因。儿童多系统炎症综合征（MIS-C）是近年来发现的一种罕见的儿童炎症性疾病，由严重急性呼吸综合征冠状病毒2感染引起；这种疾病与KD有重叠。本文综述了与KD相关的免疫炎症反应和血管内皮功能障碍的研究进展，以及KD与MIS-C之间的差异。
