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生长抑素样免疫反应性在中枢和外周神经元高尔基体中的定位。

Localization of somatostatin-like immunoreactivity in the Golgi apparatus of central and peripheral neurons.

作者信息

Johansson O

出版信息

Histochemistry. 1978 Dec 1;58(3):167-76. doi: 10.1007/BF00495716.

DOI:10.1007/BF00495716
PMID:365837
Abstract

With the indirect immunofluorescence technique of Coons and collaborators somatostatin-like immunoreactivity (SLI) was observed in certain neurons of the central and peripheral nervous system of the rat. In the cell bodies a strong SLI was observed with a distribution resembling that of the Golgi apparatus. In addition a weak SLI was diffusely distributed in the cytoplasm. After photography the sections processed for immunocytochemistry were stained with the thiamine pyrophosphatase technique of Novikoff and Goldfischer. The latter technique is assumed to be a specific marker for the Golgi complex. It was found that the strong SLI and the thiamine pyrophosphatase activity had an identical distribution. Thus, one pool of somatostatin appears to be localized to the Golgi apparatus.

摘要

采用库恩斯及其合作者的间接免疫荧光技术，在大鼠中枢和外周神经系统的某些神经元中观察到了生长抑素样免疫反应性（SLI）。在细胞体中观察到强烈的SLI，其分布类似于高尔基体。此外，微弱的SLI弥散分布于细胞质中。免疫细胞化学处理后的切片拍照后，用诺维科夫和戈德菲舍尔的硫胺素焦磷酸酶技术进行染色。后一种技术被认为是高尔基体复合体的特异性标记。结果发现，强烈的SLI和硫胺素焦磷酸酶活性具有相同的分布。因此，生长抑素的一个池似乎定位于高尔基体。

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本文引用的文献

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Vasoactive intestinal polypeptide and the nervous system: immunohistochemical evidence for localization in central and peripheral neurons, particularly intracortical neurons of the cerebral cortex.血管活性肠多肽与神经系统：免疫组织化学证据表明其定位于中枢和外周神经元，尤其是大脑皮质的皮质内神经元。
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