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人类婴儿大脑的多层面图谱。

Multifaceted atlases of the human brain in its infancy.

机构信息

Department of Radiology and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA.

出版信息

Nat Methods. 2023 Jan;20(1):55-64. doi: 10.1038/s41592-022-01703-z. Epub 2022 Dec 30.

Abstract

Brain atlases are spatial references for integrating, processing, and analyzing brain features gathered from different individuals, sources, and scales. Here we introduce a collection of joint surface-volume atlases that chart postnatal development of the human brain in a spatiotemporally dense manner from two weeks to two years of age. Our month-specific atlases chart normative patterns and capture key traits of early brain development and are therefore conducive to identifying aberrations from normal developmental trajectories. These atlases will enhance our understanding of early structural and functional development by facilitating the mapping of diverse features of the infant brain to a common reference frame for precise multifaceted quantification of cortical and subcortical changes.

摘要

脑图谱是整合、处理和分析来自不同个体、来源和尺度的脑特征的空间参考。在这里,我们介绍了一系列联合表面-体积图谱,以时空密集的方式描绘了人类大脑从两周到两岁的出生后发育过程。我们的月龄特异性图谱描绘了正常模式,并捕获了早期大脑发育的关键特征,因此有助于识别偏离正常发育轨迹的情况。这些图谱将通过将婴儿大脑的各种特征映射到共同的参考框架,促进对皮质和皮质下变化的精确多方面量化,从而增强我们对早期结构和功能发育的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/275b/9834057/b3d825661aca/41592_2022_1703_Fig1_HTML.jpg

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