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发酵液的高效液相色谱分析：头孢菌素C和泰乐菌素

High performance liquid chromatographic analysis of fermentation broths: cephalosporin C and tylosin.

作者信息

Kennedy J H

出版信息

J Chromatogr Sci. 1978 Oct 10;16(10):492-5. doi: 10.1093/chromsci/16.10.492.

DOI:10.1093/chromsci/16.10.492
PMID:365876
Abstract

Procedures are described for the analysis of cephalosporin C or tylosin in fermentation broths by high performance liquid chromatography (HPLC). Quantitation of the major components in cephalosporin C broths was done by a system involving separation by an ion-pair technique. Tylosin data were obtained using a reverse phase method. A method of equating uv potency of tylosin to microbiological potency is discussed. A comparison of HPLC with a microbiological method for the determination of tylosin concentration is also made.

摘要

描述了通过高效液相色谱法（HPLC）分析发酵液中头孢菌素C或泰乐菌素的方法。头孢菌素C发酵液中主要成分的定量分析采用离子对技术进行分离的系统。泰乐菌素的数据通过反相法获得。讨论了一种将泰乐菌素的紫外效价与微生物效价等同的方法。还对HPLC法和微生物法测定泰乐菌素浓度进行了比较。

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