Zhou Daoying, Duan Zhen, Li Zhenyu, Ge Fangfang, Wei Ran, Kong Lingsuo
Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Department of Provincial Clinical College, Wannan Medical College, Wuhu, China.
Front Pharmacol. 2022 Dec 14;13:1091779. doi: 10.3389/fphar.2022.1091779. eCollection 2022.
It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor development. The tumor microenvironment (TME) is composed of tumor cells, various immune cells, cytokines, and extracellular matrix, among other factors, and is a complex niche supporting the survival and development of tumor cells and through which they interact and co-evolve with other tumor cells. In recent years, there has been a renewed interest in glycolysis and the TME. Many studies have found that glycolysis promotes tumor growth, metastasis, and chemoresistance, as well as inhibiting the apoptosis of tumor cells. In addition, lactic acid, a metabolite of glycolysis, can also accumulate in the TME, leading to reduced extracellular pH and immunosuppression, and affecting the TME. This review discusses the significance of glycolysis in tumor development, its association with the TME, and potential glycolysis-targeted therapies, to provide new ideas for the clinical treatment of tumors.
众所周知，即使在有氧的情况下，肿瘤细胞主要依靠有氧糖酵解来产生能量，并且糖酵解是肿瘤发生和发展的一个已知调节因子。肿瘤微环境（TME）由肿瘤细胞、各种免疫细胞、细胞因子和细胞外基质等多种因素组成，是一个支持肿瘤细胞生存和发展的复杂生态位，肿瘤细胞通过它与其他肿瘤细胞相互作用并共同进化。近年来，人们对糖酵解和肿瘤微环境重新产生了兴趣。许多研究发现，糖酵解促进肿瘤生长、转移和化疗耐药性，同时抑制肿瘤细胞凋亡。此外，糖酵解的代谢产物乳酸也会在肿瘤微环境中积累，导致细胞外pH值降低和免疫抑制，并影响肿瘤微环境。本文综述了糖酵解在肿瘤发展中的意义、其与肿瘤微环境的关联以及潜在的糖酵解靶向治疗方法，为肿瘤的临床治疗提供新思路。
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