Ning Wenwen, Wu Bin, Chen Yijie, Lian Jiejing, Chen Yiming
Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310003, P.R. China.
Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang 310008, P.R. China.
Exp Ther Med. 2022 Dec 6;25(1):50. doi: 10.3892/etm.2022.11749. eCollection 2023 Jan.
Pre-eclampsia (PE) is a complicated pregnancy-specific disease and is considered the primary reason for maternal and foetal mortality and morbidity. PE has a multifactorial pathogenesis but the causes of PE remain unclear. The functions of trophoblasts, including differentiation, proliferation, migration, invasion and apoptosis, are essential for successful pregnancy. During the early stages of placental development, trophoblasts are strictly regulated by several molecular pathways; however, an imbalance of these molecular pathways can lead to severe placental lesions and pregnancy complications. Certain microRNAs (miRs) are abnormally expressed in PE, with several miRs involved in the regulation of pregnancy-associated genes. The present review discusses the miRs regulating trophoblast function, how they affect the pathogenesis of PE and evaluating the possibility of miRs in screening, diagnosis and treatment of PE.
子痫前期（PE）是一种复杂的妊娠特异性疾病，被认为是孕产妇和胎儿死亡及发病的主要原因。PE的发病机制具有多因素性，但PE的病因仍不清楚。滋养层细胞的功能，包括分化、增殖、迁移、侵袭和凋亡，对于成功妊娠至关重要。在胎盘发育的早期阶段，滋养层细胞受到多种分子途径的严格调控；然而，这些分子途径的失衡可导致严重的胎盘病变和妊娠并发症。某些微小RNA（miRs）在PE中异常表达，其中一些miRs参与妊娠相关基因的调控。本综述讨论了调节滋养层细胞功能的miRs，它们如何影响PE的发病机制，以及评估miRs在PE筛查、诊断和治疗中的可能性。
