Degtiar' V G
Probl Endokrinol (Mosk). 1987 May-Jun;33(3):63-6.
The effect of testosterone (T), 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol) and 5 alpha-and-rostane-3 beta, 17 beta-diol (3 beta-diol) on the uterus of immature rats was studied in combined with estradiol-17 beta (E2) and separate intraperitoneal administration. Repeated administration of T (100 micrograms per 100 g of body mass) caused no changes in the uterine mass whereas a similar dose of 3 alpha-diol resulted in a noticeable effect (0.05 greater than greater than p less than 0.1). 3 beta-diol administered repeatedly at a dose of 1.00 microgram per 100 g of body mass, produced the same uterotropic effect like E2. In combined administration of the above androgens (100 micrograms) and E2 (10 micrograms) 3 alpha-diol only inhibited the uterotropic effect of E2.
通过单独腹腔注射以及与雌二醇 - 17β（E2）联合注射，研究了睾酮（T）、5α - 雄烷 - 3α，17β - 二醇（3α - 二醇）和5α - 雄烷 - 3β，17β - 二醇（3β - 二醇）对未成熟大鼠子宫的影响。重复注射T（每100 g体重100微克）不会引起子宫重量的变化，而相同剂量的3α - 二醇则产生显著影响（0.05＞p＜0.1）。以每100 g体重1.00微克的剂量重复注射3β - 二醇，产生了与E2相同的促子宫生长作用。在上述雄激素（100微克）和E2（10微克）联合注射时，只有3α - 二醇抑制了E2的促子宫生长作用。
