Vinogradov V A, Degtiar' V G, Krivosheev O G, Miloserdov Iu V, Rubina A Iu
Probl Endokrinol (Mosk). 1987 May-Jun;33(3):66-70.
After chronic administration of a new neuropeptide (hydra growth activator--HGA) to male and female Wistar rats from the 29th to 43rd day of life at a dose of 30 micrograms X kg-1 of body mass a study was made of [3H] testosterone, [3H] 5 alpha-dehydrotestosterone [( 3H] DHT) and [3H] 5 alpha-androstane-3 beta, 17 beta-diol metabolism in gonadal homogenates of the animals. In testis homogenates HGA administration was shown to influence the production of [3H] 3 beta-diol from [3H] DHT only. In female rats HGA administration made an effect on the majority of enzymes of androgen metabolism in the ovaries of animals with the closed and open vagina. Basing on changes in enzymatic activity of androgen metabolism in the gonads of rats in chronic HGA administration in the period of male pubescence a conclusion was made that it acted as a pubescence accelerating factor.
从出生后第29天至43天，以30微克/千克体重的剂量对雄性和雌性Wistar大鼠长期施用一种新的神经肽（九头蛇生长激活剂——HGA）后，对动物性腺匀浆中[3H]睾酮、[3H]5α-脱氢睾酮[（3H）DHT]和[3H]5α-雄甾烷-3β，17β-二醇的代谢进行了研究。在睾丸匀浆中，施用HGA仅显示会影响[3H]DHT产生[3H]3β-二醇。在雌性大鼠中，施用HGA对阴道闭合和开放的动物卵巢中大多数雄激素代谢酶都有影响。基于在雄性青春期期间长期施用HGA时大鼠性腺中雄激素代谢酶活性的变化，得出结论：它可作为青春期加速因子。
