Ezzat Dina, Barcellini Bastien, Meier Julie, Duc-Ha Edouard, Mathis Jérôme
Centre Hospitalier Bienne, Frauenklinik, Bienne, Switzerland.
AJOG Glob Rep. 2023 Feb;3(1):100155. doi: 10.1016/j.xagr.2022.100155. Epub 2022 Dec 27.
The human monkeypox virus is a zoonotic orthopoxvirus initially discovered in Africa that causes a disease similar to smallpox with less severe symptoms. Since May 2022, the virus is being transmitted from human to human at an increasing rate outside of Africa. Although monkeypox infection was endemic in Africa, it had sporadic surges in recent years. This has led the World Health Organization to declare its highest alert level on July 25, 2022. In Switzerland only, 456 individuals have been diagnosed with monkeypox infection from May 19, 2022, to August 29, 2022. To date, >99% of patients with monkeypox infection are men, in particular those who have sex with other men. Clinical cases of women with monkeypox infection are still very rare but will more likely be seen. With this case, we have highlighted the fact that this zoonosis is also starting to spread among women. We have presented the case of a female patient living in Switzerland who presented to our gynecologic emergency department for painful vulvar lesions after an episode of upper respiratory tract infection. The monkeypox infection was confirmed with a real-time polymerase chain reaction analysis at the University Hospital of Geneva, a center of reference for monkeypox in Switzerland. Shortly after, the patient developed generalized and typical lesions on the whole body.
人类猴痘病毒是一种人畜共患的正痘病毒，最初在非洲被发现，可引发与天花类似但症状较轻的疾病。自2022年5月以来，该病毒在非洲以外地区的人际传播率不断上升。尽管猴痘感染在非洲呈地方性流行，但近年来也有零星的激增情况。这导致世界卫生组织于2022年7月25日发布了最高级别警报。仅在瑞士，从2022年5月19日至2022年8月29日就有456人被诊断感染猴痘。迄今为止，超过99%的猴痘感染患者为男性，尤其是与其他男性发生性行为的人。女性猴痘感染的临床病例仍然非常罕见，但今后可能会更多见。通过这个病例，我们强调了这种人畜共患病也开始在女性中传播这一事实。我们介绍了一名居住在瑞士的女性患者的病例，她在上呼吸道感染后因外阴疼痛性病变到我们的妇科急诊科就诊。在瑞士猴痘参考中心日内瓦大学医院通过实时聚合酶链反应分析确诊为猴痘感染。此后不久，患者全身出现了广泛性的典型病变。
