Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Endocrinology, Children's Hospital School of Medicine, Zhejiang University, Hangzhou, China.
Front Public Health. 2022 Dec 15;10:1014942. doi: 10.3389/fpubh.2022.1014942. eCollection 2022.
The hospitalization and mortality rate from COVID-19 appears to be higher in liver transplant recipients when compared with general populations. Vaccination is an effective strategy to reduce the risk during the COVID-19 pandemic. We aimed to evaluate COVID-19 vaccine hesitancy in liver transplant recipients.
In April 2022, we conducted an online-based survey through WeChat platform to investigate the vaccination hesitancy among liver transplant recipients followed at Shanghai Renji Hospital and further explore possible influencing factors. Survey items included multiple choice, Likert-type rating scale and open-ended answers. Participants were classified as no hesitancy group and hesitancy group. Using univariate analysis, ROC curve analysis and multiple logistic regression to evaluate associations between baseline characteristics and COVID-19 vaccine hesitancy.
449 liver transplant recipients participated in the survey with 299 (66.6%) of them being categorized as vaccine hesitancy. In no hesitancy group, 73 (48.7%) recipients had completed vaccination, while 77 (51.3%) were not yet but intended to be vaccinated. In contrast, 195 (65.2%) recipients in hesitancy group were hesitant to get vaccinated, while the remaining 104 (34.8%) refused. The most common side effect was injection arm pain ( = 9, 12.3%). The common reasons for vaccine willingness was trusted in the effectiveness of the vaccine and fear of contracting COVID-19. The most common reason for vaccination hesitancy is fear of side effects, and the most effective improvement was the support from the attending physician. Factors associated with vaccine hesitancy include female sex, influenza vaccination status, awareness of the importance and safety of vaccine, attitudes of doctors and others toward vaccine, medical worker source information of vaccine, relative/friend with medical background, total score of VHS (Vaccine Hesitancy Scale), accessibility of vaccine.
For liver transplant recipients, COVID-19 vaccine is an important preventive measure. Identifying the factors influencing COVID-19 vaccine hesitancy is therefore critical to developing a promotion plan. Our study shows that more comprehensive vaccine knowledge popularization and relevant medical workers' training can effectively improve the acceptance of COVID-19 vaccine in this population.
与普通人群相比，肝移植受者 COVID-19 的住院率和死亡率似乎更高。接种疫苗是减少 COVID-19 大流行期间风险的有效策略。我们旨在评估肝移植受者对 COVID-19 疫苗的犹豫态度。
2022 年 4 月，我们通过微信平台进行了一项基于网络的调查，以调查上海仁济医院随访的肝移植受者的疫苗接种犹豫情况，并进一步探讨可能的影响因素。调查项目包括多项选择、李克特量表和开放式回答。参与者分为无犹豫组和犹豫组。使用单因素分析、ROC 曲线分析和多因素逻辑回归来评估基线特征与 COVID-19 疫苗犹豫之间的关联。
共有 449 名肝移植受者参与了调查，其中 299 名（66.6%）被归类为疫苗犹豫。在无犹豫组中，73 名（48.7%）受者已完成接种，而 77 名（51.3%）尚未接种但计划接种。相比之下，在犹豫组中，195 名（65.2%）受者对接种疫苗犹豫不决，而其余 104 名（34.8%）拒绝接种。最常见的副作用是注射部位疼痛（n=9，12.3%）。愿意接种疫苗的常见原因是信任疫苗的有效性和担心感染 COVID-19。疫苗犹豫的最常见原因是担心副作用，最有效的改善措施是主治医生的支持。与疫苗犹豫相关的因素包括女性、流感疫苗接种情况、对疫苗重要性和安全性的认识、医生和其他人对疫苗的态度、疫苗来源信息、有医学背景的亲戚/朋友、疫苗犹豫量表（VHS）总分、疫苗可及性。
对于肝移植受者而言，COVID-19 疫苗是一种重要的预防措施。因此，确定影响 COVID-19 疫苗犹豫的因素对于制定推广计划至关重要。我们的研究表明，更全面的疫苗知识普及和相关医务人员培训可以有效提高该人群对 COVID-19 疫苗的接受程度。
