Li Na, Liu Qiong, Zhang Yimu, Yang Zhongyi, Shi Xuefeng, Gu Yu
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
School of Life Sciences, Westlake University, Hangzhou 310000, China.
iScience. 2022 Dec 7;26(1):105752. doi: 10.1016/j.isci.2022.105752. eCollection 2023 Jan 20.
In primary visual cortex (V1), critical period for ocular dominance (OD) plasticity is a well-defined developmental stage to shape neuronal circuits based on visual experience. Recent studies showed that V1-like OD plasticity existed in mouse dorsal lateral geniculate nucleus (dLGN). It is still unclear what the exact time window is and how neural circuits contribute to OD plasticity in dLGN. Using electrophysiology, we defined a critical period for OD plasticity in dLGN from eye opening to puberty. There also existed an innate process of OD formation from contralateral to equal bias in dLGN binocular neurons. Instant V1 inactivation with muscimol had no effect on OD bias or plasticity. Short-term V1 inactivation with N-methyl-d-aspartate reversed the formation of equal OD bias, while long-term V1 inactivation retained dLGN development to an immature stage.
在初级视觉皮层（V1）中，眼优势（OD）可塑性的关键期是一个明确的发育阶段，可根据视觉经验塑造神经元回路。最近的研究表明，小鼠背外侧膝状核（dLGN）中存在类似V1的OD可塑性。目前尚不清楚确切的时间窗口是什么，以及神经回路如何促进dLGN中的OD可塑性。我们使用电生理学方法，定义了从睁眼到青春期dLGN中OD可塑性的关键期。dLGN双眼神经元中也存在从对侧偏向到均等偏向的OD形成的先天过程。用蝇蕈醇瞬间使V1失活对OD偏向或可塑性没有影响。用N-甲基-D-天冬氨酸短期使V1失活可逆转均等OD偏向的形成，而长期使V1失活则使dLGN发育停滞在未成熟阶段。
