Qian Hu, He Li, Ye Zhimin, Wei Zairong, Ao Jun
Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of Pathology, School of Basic Medical Sciences, Central South University, Changsha, China.
Mater Today Bio. 2022 Dec 17;18:100523. doi: 10.1016/j.mtbio.2022.100523. eCollection 2023 Feb.
Intervertebral disc degeneration (IDD)-induced low back pain significantly influences the quality of life, placing a burden on public health systems worldwide. Currently available therapeutic strategies, such as conservative or operative treatment, cannot effectively restore intervertebral disc (IVD) function. Decellularized matrix (DCM) is a tissue-engineered biomaterial fabricated using physical, chemical, and enzymatic technologies to eliminate cells and antigens. By contrast, the extracellular matrix (ECM), including collagen and glycosaminoglycans, which are well retained, have been extensively studied in IVD regeneration. DCM inherits the native architecture and specific-differentiation induction ability of IVD and has demonstrated effectiveness in IVD regeneration in vitro and in vivo. Moreover, significant improvements have been achieved in the preparation process, mechanistic insights, and application of DCM for IDD repair. Herein, we comprehensively summarize and provide an overview of the roles and applications of DCM for IDD repair based on the existing evidence to shed a novel light on the clinical treatment of IDD.
椎间盘退变（IDD）引发的下腰痛严重影响生活质量，给全球公共卫生系统带来负担。目前可用的治疗策略，如保守治疗或手术治疗，无法有效恢复椎间盘（IVD）功能。脱细胞基质（DCM）是一种利用物理、化学和酶技术制造的组织工程生物材料，用于去除细胞和抗原。相比之下，细胞外基质（ECM），包括保留良好的胶原蛋白和糖胺聚糖，已在IVD再生中得到广泛研究。DCM继承了IVD的天然结构和特定分化诱导能力，并已在体外和体内的IVD再生中证明了有效性。此外，在DCM用于IDD修复的制备过程、作用机制和应用方面已取得显著进展。在此，我们基于现有证据全面总结并概述DCM在IDD修复中的作用和应用，为IDD的临床治疗提供新的思路。
