Cannon D S, Carrell L E
Psychology Service, Veterans Administration Medical Center, Dallas, TX 75216.
Pharmacol Biochem Behav. 1987 Sep;28(1):53-6. doi: 10.1016/0091-3057(87)90011-6.
Ethanol (EtOH) oral self-administration studies using rats have had inconsistent outcomes: studies in which rats are fluid deprived report decreasing EtOH intake over trials, whereas studies not employing fluid deprivation report increasing intake over trials. The present study supports the hypothesis that differential taste aversion learning may account for some of this discrepancy. This study indicates that taste aversion learning is maximized under fluid deprivation conditions and that "latent inhibition," i.e., exposure to non-intoxicating amounts of the EtOH solution prior to conditioning, reduces taste aversion learning. It is suggested that the effect of fluid deprivation on taste aversion resulting from EtOH self-administration may be at least in part due to the development of latent inhibition in non-deprived animals during initial exposure to the EtOH solution.
使用大鼠进行的乙醇（EtOH）口服自我给药研究结果并不一致：在那些使大鼠处于液体剥夺状态的研究中，报告显示随着试验进行乙醇摄入量减少，而在未采用液体剥夺的研究中，报告显示随着试验进行摄入量增加。本研究支持这样一种假说，即不同的味觉厌恶学习可能是造成这种差异的部分原因。该研究表明，味觉厌恶学习在液体剥夺条件下会达到最大化，并且“潜伏抑制”，即在条件作用之前接触非致醉量的乙醇溶液，会降低味觉厌恶学习。有人提出，液体剥夺对乙醇自我给药所导致的味觉厌恶的影响，可能至少部分是由于在初次接触乙醇溶液期间，未被剥夺的动物中产生了潜伏抑制。
