Department of Pediatric Dentistry, Faculty of Dentistry, Nuh Naci Yazgan University, TR-38170, Kayseri, Türkiye.
Department of Restorative Dentistry, Faculty of Dentistry, Mersin University, TR-33343, Mersin, Türkiye.
BMC Oral Health. 2023 Jan 2;23(1):1. doi: 10.1186/s12903-022-02698-x.
The effects of topical fluoride applications on the release of monomer ingredients from resin-based dental materials by immersion in various extraction solutions are unclear. The aim of this study was to determine the effect of topical fluorides (APF and NaF) on the elution of residual monomers (Bis-GMA, TEGDMA, UDMA, and HEMA) from resin-based materials.
Ninety specimens were prepared, 30 bulk-fill composite resin, 30 nanohybrid universal composite resin, and 30 polyacid-modified composite resin (compomer). These were randomly divided into three groups based on fluoride application procedures. Each specimen was kept in 75% ethanol solution, and residual monomers released from materials were analyzed using high-performance liquid chromatography (HPLC) after 10 min, 1 h, 24 h, and 30 days. The groups were compared using the Mann Whitney U and Kruskal Wallis tests. Measurements were analyzed using the Friedman and Wilcoxon signed-rank tests.
Fluoride applications generally had no considerable effect on the amount of residual monomer released from resin-based restorative materials. The amount of monomer release after topical APF application was similar to the release in the control group and was lower than the release in the NaF group. The release of monomers from the resin-based material used in the study did not approach toxic levels at the applied time intervals. The compomer released lower amounts of monomer than other resin-based materials.
Fluoride applications do not increase monomer release from resin-based restorative materials. However, compomers should be employed by clinicians due to their lower monomer release compared to other resin restorative materials. The release of monomers from all the resin-based materials did not approach toxic levels at the applied time intervals.
局部用氟化物应用于浸泡在不同提取溶液中的树脂基牙科材料对单体成分释放的影响尚不清楚。本研究旨在确定局部氟化物（APF 和 NaF）对树脂基材料中残留单体（Bis-GMA、TEGDMA、UDMA 和 HEMA）洗脱的影响。
制备了 90 个样本，包括 30 个块状填充型复合树脂、30 个纳米复合通用型复合树脂和 30 个聚酸改性复合树脂（复合体）。根据氟化物应用程序将这些样本随机分为三组。将每个样本保存在 75%乙醇溶液中，使用高效液相色谱法（HPLC）分析材料释放的残留单体，10 分钟、1 小时、24 小时和 30 天后。使用 Mann Whitney U 和 Kruskal Wallis 检验比较各组。使用 Friedman 和 Wilcoxon 符号秩检验分析测量结果。
氟化物应用通常对树脂基修复材料释放的残留单体量没有显著影响。局部应用 APF 后单体释放量与对照组相似，低于 NaF 组。在所应用的时间间隔内，研究中使用的树脂基材料释放的单体量未达到毒性水平。复合体释放的单体量低于其他树脂基材料。
氟化物应用不会增加树脂基修复材料的单体释放量。然而，由于与其他树脂修复材料相比，复合树脂释放的单体较少，因此临床医生应选用复合树脂。在所应用的时间间隔内，所有树脂基材料释放的单体均未达到毒性水平。
