Department of Pediatric Dentistry, Faculty of Dentistry, Inonu University, Malatya, Turkey.
Department of Pharmacy Services, Health Services Vocational School, Inonu University, Malatya, Turkey.
BMC Oral Health. 2022 Jun 13;22(1):232. doi: 10.1186/s12903-022-02260-9.
The choice of the restorative resin material to be used in pediatric dentistry is of a great importance due to the cytotoxic effects caused by residual monomers. In this study, it was aimed to investigate the amount of residual monomer released over time from different resin-based restorative materials, which are widely used in pediatric dentistry, by using high performance liquid chromatography with photodiode array detector (HPLC-PDA).
The compomers in all colors (Twinky Star and Glasiositte A), two composites with different hybrid properties (Arabesk-GrandioSO), and RMGIC (Ionolux) samples with 2 × 5 mm diameters were prepared. The samples were polymerized with an LED light unit (CELALUX 2, VOCO, Cuxhaven, Germany) and then finishing-polishing procedures were applied. A total of 156 samples were obtained, 13 samples in each of the 12 groups. The amount of residual monomer (BIS-GMA; HEMA, TEGDMA, UDMA) (µg/mL) released into the 75% ethanol solution was determined at different times, (1st hour, 1st, 7th, 14th, and 21st day) by using HPLC-PDA.
The residual monomer release continued on day 21 and BIS-GMA was the most released monomer in all groups. HEMA release showed a maximum increase in all the materials at day 7. The highest amount of residual monomer was detected in the gold-colored compomer. HEMA and BIS-GMA release from RMGIC was less than others in all time frames.
The color and composition of resin-based restorative materials affect the amount of residual monomer. Pediatric dentists should prefer gold-colored compomers less than others as a restorative material, especially in deep cavities. More studies are needed about the subject.
由于残留单体的细胞毒性作用，选择用于儿童牙科的修复树脂材料非常重要。本研究旨在通过使用带光电二极管阵列检测器的高效液相色谱法（HPLC-PDA），研究在儿童牙科中广泛使用的不同树脂基修复材料随时间释放的残留单体量。
制备了所有颜色的复合树脂（Twinky Star 和 Glasiositte A）、两种具有不同混合特性的复合材料（Arabesk-GrandioSO）和 RMGIC（Ionolux），直径为 2×5mm。使用 LED 灯单元（CELALUX 2，VOCO，Cuxhaven，德国）聚合样品，然后进行修整-抛光处理。共获得 156 个样本，每个 12 组中的 13 个样本。通过 HPLC-PDA 在不同时间（第 1 小时、第 1 天、第 7 天、第 14 天和第 21 天）确定释放到 75%乙醇溶液中的残留单体（BIS-GMA；HEMA、TEGDMA、UDMA）（µg/mL）的量。
残留单体释放持续到第 21 天，BIS-GMA 是所有组中释放最多的单体。在所有材料中，HEMA 的释放在第 7 天达到最大增加。金颜色的复合树脂中检测到的残留单体量最高。在所有时间范围内，RMGIC 释放的残留单体量均少于其他材料。
树脂基修复材料的颜色和成分会影响残留单体的量。儿童牙医应优先选择其他颜色的复合树脂作为修复材料，尤其是在深龋中。需要对此主题进行更多的研究。
