Point mutations in the gene encoding IP3 receptor subtype 3 cause impairment in T-cell and B-cell immune responses via dysfunctional Ca mobilization.
作者信息
Nadeem Ahmed, Ahmad Sheikh F
机构信息
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
出版信息
Cell Mol Immunol. 2023 Feb;20(2):214-216. doi: 10.1038/s41423-022-00938-2. Epub 2023 Jan 4.
Abstract
摘要
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Point mutations in the gene encoding IP3 receptor subtype 3 cause impairment in T-cell and B-cell immune responses via dysfunctional Ca mobilization.编码三磷酸肌醇受体亚型3的基因中的点突变通过功能失调的钙动员导致T细胞和B细胞免疫反应受损。
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本文引用的文献
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Disrupted Ca homeostasis and immunodeficiency in patients with functional IP receptor subtype 3 defects.功能性 IP 受体亚型 3 缺陷患者的钙稳态紊乱和免疫缺陷。
Cell Mol Immunol. 2023 Jan;20(1):11-25. doi: 10.1038/s41423-022-00928-4. Epub 2022 Oct 27.
2
Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications.钙稳态与癌症：以内质网为中心的细胞器通讯所带来的见解
Trends Cell Biol. 2023 Apr;33(4):312-323. doi: 10.1016/j.tcb.2022.07.004. Epub 2022 Jul 29.
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Calcium-release channels: structure and function of IP receptors and ryanodine receptors.钙释放通道：肌醇1,4,5-三磷酸受体和兰尼碱受体的结构与功能
Physiol Rev. 2022 Jan 1;102(1):209-268. doi: 10.1152/physrev.00033.2020. Epub 2021 Jul 19.
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The discovery and development of IP3 receptor modulators: an update.IP3 受体调节剂的发现和发展：最新进展。
Expert Opin Drug Discov. 2021 Jun;16(6):709-718. doi: 10.1080/17460441.2021.1858792. Epub 2021 Jan 6.
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Inositol 1,4,5-Trisphosphate Receptors in Human Disease: A Comprehensive Update.人类疾病中的肌醇1,4,5-三磷酸受体：全面更新
J Clin Med. 2020 Apr 12;9(4):1096. doi: 10.3390/jcm9041096.
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The Role of Calcium-Calcineurin-NFAT Signaling Pathway in Health and Autoimmune Diseases.钙调磷酸酶-NFAT 信号通路在健康和自身免疫性疾病中的作用。
Front Immunol. 2020 Mar 10;11:195. doi: 10.3389/fimmu.2020.00195. eCollection 2020.
7
Structure and Function of IP Receptors.离子通道受体的结构与功能。
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Calcium signalling in T cells.T 细胞中的钙信号转导。
Nat Rev Immunol. 2019 Mar;19(3):154-169. doi: 10.1038/s41577-018-0110-7.
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