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蜂蜜敷料在藏毛窦囊肿愈合中的价值:一项前瞻性随机单中心试验。

The value of honey dressings in pilonidal cyst healing: a prospective randomized single-center trial.

机构信息

Service de Chirurgie Digestive, Centre Hospitalier Départemental de Vendée, La Roche-sur-Yon, France.

Unité de Recherche Clinique, Centre Hospitalier Départemental de Vendée, La Roche-sur-Yon, France.

出版信息

Tech Coloproctol. 2023 Sep;27(9):721-727. doi: 10.1007/s10151-022-02740-8. Epub 2023 Jan 4.

Abstract

BACKGROUND

Honey is described as a wound healing agent. Many virtues have been attributed to it, in particular, antibacterial properties. The aim of our study was to evaluate its value in healing of wounds after wide excision on pilonidal cyst healing.

METHODS

A prospective randomized trial was conducted from March 2016 to February 2022 which included patients with a persistent non healed wound which required packing 6 weeks after pilonidal cyst excision. Patients were randomly allocated to simple alginate wick dressings or the same design plus honey.

RESULTS

Fifty patients were included in each arm. There were 57 men and 43 women. The median age was 22 years (range 19-28 years). The mean healing time was 61 (± 44) days in the wick + honey group compared to 78 (± 55) days in the simple alginate wick group (p = 0.094). There was no significant difference between the two groups in terms of time off work and time without physical activity The VQ-Dermato quality of life score was equivalent in both groups.

CONCLUSIONS

Tolerability for honey dressings is good and is equivalent to that of alginate dressings in cavity wound care. This trial did not reach a significant difference in its primary endpoint but it shows the value of honey in this indication, although its use requires further study.

TRIAL REGISTRATION NUMBER

CLINICAL TRIALS: NCT02485860 and EUDRACT: 2015-A00452-47 (10/03/2015).

摘要

背景

蜂蜜被描述为一种伤口愈合剂。它具有许多优点,特别是具有抗菌特性。我们的研究旨在评估其在广泛切除后对藏毛窦囊肿愈合的伤口愈合的价值。

方法

这是一项前瞻性随机试验,于 2016 年 3 月至 2022 年 2 月进行,纳入了需要在藏毛窦切除后 6 周进行填塞的持续未愈合伤口的患者。患者被随机分配到单纯藻酸盐wick 敷料或相同设计加蜂蜜的敷料。

结果

每组 50 例患者。有 57 名男性和 43 名女性。中位年龄为 22 岁(范围 19-28 岁)。wick+蜂蜜组的平均愈合时间为 61(±44)天,而单纯藻酸盐 wick 组为 78(±55)天(p=0.094)。在停工时间和无体力活动时间方面,两组之间无显著差异。两组的 VQ-Dermato 生活质量评分相当。

结论

蜂蜜敷料的耐受性良好,在腔洞伤口护理方面与藻酸盐敷料相当。本试验在其主要终点未达到显著差异,但它表明了蜂蜜在这一适应证中的价值,尽管其使用需要进一步研究。

临床试验注册号

NCT02485860 和 EUDRACT:2015-A00452-47(2015 年 3 月 10 日)。

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