Safadi Mhd F, Ghareb Khaldoun, Daher Ayham, Dettmer Marius, Shamma Hadeel, Doll Dietrich
Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, DEU.
Colorectal and Proctologic Surgery, Charme Day Surgery Center, Dubai, ARE.
Cureus. 2022 Jul 20;14(7):e27054. doi: 10.7759/cureus.27054. eCollection 2022 Jul.
Carcinoma secondary to pilonidal disease is very rare with fewer than 130 reported cases so far. It is presumed that underreporting and underpublishing contribute to the low reported incidence.
A post was published on a closed Facebook group with about 30,000 Syrian doctors asking if anyone had ever seen a patient with pilonidal carcinoma before. The patients' data were collected retrospectively from the treating physicians.
Between 2010 and 2019, we identified eight patients with pilonidal carcinoma. All patients were males with a mean age of 55.5 years. The mean interval between diagnosis of pilonidal disease and diagnosis of carcinoma was 6.9 years. A growing ulcer on the background of a pilonidal sinus disease was the presenting complaint in 50% of cases. Three patients were lost from follow-up after the diagnosis due to referral. All other five patients underwent surgical resection and three of them received postoperative chemoradiation. Four patients were followed for six months or longer: two died of metastases, one survived after recurrence and re-excision, and one survived with no recurrence.
This paper presents the largest cohort of pilonidal carcinoma so far and the first that describes the disease in the Syrian population. Due to underreporting, the real incidence of pilonidal carcinoma exceeds what is reported so far in the literature.
藏毛窦继发的癌非常罕见，迄今为止报告的病例不到130例。据推测，报告不足和发表不足导致了报告发病率较低。
在一个约有30000名叙利亚医生的封闭Facebook群组上发布了一篇帖子，询问是否有人曾见过藏毛窦癌患者。患者数据从治疗医生处进行回顾性收集。
2010年至2019年期间，我们确定了8例藏毛窦癌患者。所有患者均为男性，平均年龄55.5岁。藏毛窦疾病诊断与癌症诊断之间的平均间隔为6.9年。50%的病例以藏毛窦疾病为背景的溃疡进行性加重为首发症状。3例患者在诊断后因转诊失去随访。其他5例患者均接受了手术切除，其中3例接受了术后放化疗。4例患者随访6个月或更长时间：2例死于转移，1例复发后再次切除存活，1例无复发存活。
本文介绍了迄今为止最大的藏毛窦癌队列，也是第一篇描述叙利亚人群中该疾病的文章。由于报告不足，藏毛窦癌的实际发病率超过了迄今为止文献中的报告。
