Lim L Y, Wan Lucy S C
Department of Pharmacy, National University of Singapore 10, Kent Ridge Crescent, Singapore, 0511.
Drug Dev Ind Pharm. 1995;21(3):369-373. doi: 10.3109/03639049509048117.
The effects of heat treatment on PVA films containing water soluble plasticizers were investigated. Propylene glycol, glycerol and polyethylene glycol were used as plasticizers. There was synergism between heat treatment and the presence of plasticizers in enhancing the water resistance of PVA films. In the absence of heat treatment, however, the plasticizers increased the aqueous solubility of PVA films. The plasticized films further showed a lower permeability to propranolol HC1 compared to the unplasticized films following heat treatment.
研究了热处理对含有水溶性增塑剂的聚乙烯醇（PVA）薄膜的影响。使用丙二醇、甘油和聚乙二醇作为增塑剂。在提高PVA薄膜的耐水性方面，热处理和增塑剂的存在之间存在协同作用。然而，在没有热处理的情况下，增塑剂会增加PVA薄膜在水中的溶解度。与热处理后的未增塑薄膜相比，增塑薄膜对盐酸普萘洛尔的渗透性更低。
