Ediyilyam Sreelekha, Lalitha Mahesh M, George Bini, Shankar Sarojini Sharath, Wacławek Stanisław, Černík Miroslav, Padil Vinod Vellora Thekkae
Department of Chemistry, School of Physical Sciences, Central University of Kerala, Kasaragod 671316, India.
Department of Biochemistry and Molecular Biology, School of Biological Sciences, Central University of Kerala, Kasaragod 671316, India.
Polymers (Basel). 2022 Jan 24;14(3):463. doi: 10.3390/polym14030463.
Green bionanocomposites have garnered considerable attention and applications in the pharmaceutical and packaging industries because of their intrinsic features, such as biocompatibility and biodegradability. The work presents a novel approach towards the combined effect of glycerol, tween 80 and silver nanoparticles (AgNPs) on the physicochemical properties of lyophilized chitosan (CH) scaffolds produced via a green synthesis method.The produced bionanocomposites were characterized with the help of Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscopy (SEM). The swelling behavior, water vapor transmission rate, moisture retention capability, degradation in Hanks solution, biodegradability in soil, mechanical strength and electrochemical performance of the composites were evaluated. The addition of additives to the CH matrix alters the physicochemical and biological functioning of the matrix. Plasticized scaffolds showed an increase in swelling degree, water vapor transmission rate and degradability in Hank's balanced solution compared to the blank chitosan scaffolds. The addition of tween 80 made the scaffolds more porous, and changes in physicochemical properties were observed. Green-synthesized AgNPs showed intensified antioxidant and antibacterial properties. Incorporating biogenic nanoparticles into the CH matrix enhances the polymer composites' biochemical properties and increases the demand in the medical and biological sectors. These freeze-dried chitosan-AgNPs composite scaffolds had tremendous applications, especially in biomedical fields like wound dressing, tissue engineering, bone regeneration, etc.
绿色生物纳米复合材料因其生物相容性和可生物降解性等固有特性，在制药和包装行业受到了广泛关注并得到应用。这项工作提出了一种新方法，用于研究甘油、吐温80和银纳米颗粒（AgNPs）对通过绿色合成方法制备的冻干壳聚糖（CH）支架的物理化学性质的综合影响。借助傅里叶变换红外光谱（FTIR）和扫描电子显微镜（SEM）对制备的生物纳米复合材料进行了表征。评估了复合材料的溶胀行为、水蒸气透过率、保湿能力、在汉克斯溶液中的降解、在土壤中的生物降解性、机械强度和电化学性能。向CH基质中添加添加剂会改变基质的物理化学和生物学功能。与空白壳聚糖支架相比，增塑后的支架在汉克斯平衡溶液中的溶胀度、水蒸气透过率和降解性有所增加。吐温80的添加使支架更加多孔，并观察到物理化学性质的变化。绿色合成的AgNPs表现出增强的抗氧化和抗菌性能。将生物源纳米颗粒掺入CH基质中可增强聚合物复合材料的生化性质，并增加在医疗和生物领域的需求。这些冻干的壳聚糖-AgNPs复合支架具有巨大的应用潜力，尤其是在伤口敷料、组织工程、骨再生等生物医学领域。
