Neurovirulence effects of dengue-2 viruses on the rhesus (Macaca mulatta) brain and spinal cord.
作者信息
Angsubhakorn S, Moe J B, Marchette N J, Palumbo N E, Yoksan S, Bhamarapravati N
机构信息
Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
出版信息
Southeast Asian J Trop Med Public Health. 1987 Mar;18(1):52-5.
PMID:3660068
Abstract
Vaccines prepared from attenuated virus can cause symptomatic viral infection of the central nervous system. In the present study, dengue-2 parental and its live attenuated viruses were tested by intrathalamic and intraspinal injections in rhesus monkeys. The dengue-2 viruses were found to be only very weakly neurovirulent when injected directly into the brain or spinal cord of rhesus monkeys.
摘要
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