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克罗恩病患者回肠造口原发性腺癌:一例报告

Primary adenocarcinoma of an ileostomy in a Crohn patient: a case report.

作者信息

De Deken Julie, Stavrou Gregor A

机构信息

Department of General, Visceral and Thoracic Surgery, Surgical Oncology, Klinikum Saarbrücken, Saarbrücken, Germany.

出版信息

J Surg Case Rep. 2022 Dec 30;2022(12):rjac609. doi: 10.1093/jscr/rjac609. eCollection 2022 Dec.

DOI:10.1093/jscr/rjac609
PMID:36601093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9803964/
Abstract

Proctocolectomy with ileostomy is an established surgical treatment in patients with inflammatory bowel disease. Adenocarcinoma of an ileostomy is a rare complication in long-term ileostomies. We present the case of a 69-year-old man who presented with bloody stools and a tumour at the ileostomy site 37 years after ileostomy formation. Biopsies confirmed the presence of an adenocarcinoma. Imaging did not show any metastases or advanced local infiltration. A resection of the ileostomy with a broad safety margin and reimplantation of a new Ileostomy was performed. At 18-month follow-up, there is no sign of recurrence. Ileostomy adenocarcinoma in a Crohn's disease patient is rare with only four cases described in literature. An en-bloc resection and relocation of the ileostomy is the recommended treatment. Education of patients and healthcare professionals on this long-term ileostomy complication is vital for the early diagnosis and treatment.

摘要

全结直肠切除术加回肠造口术是炎症性肠病患者已确立的外科治疗方法。回肠造口腺癌是长期回肠造口患者中罕见的并发症。我们报告一例69岁男性患者,在回肠造口形成37年后出现便血及回肠造口部位肿瘤。活检证实为腺癌。影像学检查未显示任何转移或局部进展性浸润。进行了带足够安全切缘的回肠造口切除术及新回肠造口再植术。在18个月的随访中,无复发迹象。克罗恩病患者发生回肠造口腺癌很罕见,文献中仅描述了4例。推荐的治疗方法是整块切除并重新安置回肠造口。对患者及医护人员进行关于这种长期回肠造口并发症的教育对于早期诊断和治疗至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de1f/9803964/594f1d8ebee2/rjac609f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de1f/9803964/594f1d8ebee2/rjac609f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de1f/9803964/594f1d8ebee2/rjac609f1.jpg

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1
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本文引用的文献

1
Primary squamous cell carcinoma at ileostomy site. Two case reports and review of literature.回肠造口术部位原发性鳞状细胞癌。两例报告并文献复习。
Clin Case Rep. 2020 May 27;8(8):1437-1439. doi: 10.1002/ccr3.2931. eCollection 2020 Aug.
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Small bowel adenocarcinoma in Crohn's disease: a rare but devastating complication.克罗恩病中的小肠腺癌:一种罕见但极具破坏性的并发症。
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Ileostomy adenocarcinoma in Crohn's disease.克罗恩病回肠造口腺癌。
Int J Colorectal Dis. 2020 May;35(5):963-966. doi: 10.1007/s00384-020-03554-6. Epub 2020 Mar 6.
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Primary Adenocarcinoma of an Ileostomy in Crohn's Disease.克罗恩病回肠造口原发性腺癌
ACG Case Rep J. 2016 Aug 31;3(4):e112. doi: 10.14309/crj.2016.85. eCollection 2016 Jul.
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Adenocarcinoma developing at an ileostomy: report of a case and review of the literature.回肠造口术处发生的腺癌:1例报告及文献复习
Dis Colon Rectum. 2008 May;51(5):604-9. doi: 10.1007/s10350-007-9188-x. Epub 2008 Feb 28.
8
Medical risk factors for small-bowel adenocarcinoma with focus on Crohn disease: a European population-based case-control study.以克罗恩病为重点的小肠腺癌的医学风险因素:一项基于欧洲人群的病例对照研究。
Scand J Gastroenterol. 2001 Jun;36(6):641-6. doi: 10.1080/003655201750163150.
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Familial adenomatous polyposis: a case report and histologic mucin study.家族性腺瘤性息肉病:一例报告及组织学黏液研究
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10
Squamous cell carcinoma occurring in a skin-grafted ileostomy stoma. Report of a case.发生于皮肤移植回肠造口术造口处的鳞状细胞癌。病例报告。
Dis Colon Rectum. 1987 Jun;30(6):475-8. doi: 10.1007/BF02556501.