Liu Kevin, Prasad Meena A, Lo Amy, Bellaguarda Emanuelle, Strong Scott, Hanauer Stephen B
Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Atlanta VA Medical Center, Department of Digestive Diseases, Emory University School of Medicine, Atlanta, GA.
ACG Case Rep J. 2016 Aug 31;3(4):e112. doi: 10.14309/crj.2016.85. eCollection 2016 Jul.
Although Crohn's disease has been associated with an increased risk of small bowel adenocarcinoma, primary adenocarcinoma arising from an ileostomy is a complication that has been rarely documented in Crohn's disease. Chronic small bowel inflammation may lead to development of malignancy through the dysplasia-carcinoma sequence. We report a case of a 61-year-old woman with Crohn's ileocolitis diagnosed with a primary adenocarcinoma at the ileostomy with metastases to the liver 47 years after proctocolectomy, and review the literature.
尽管克罗恩病与小肠腺癌风险增加有关，但回肠造口术引发的原发性腺癌是克罗恩病中鲜有记录的一种并发症。慢性小肠炎症可能通过发育异常-癌序列导致恶性肿瘤的发生。我们报告一例61岁患有克罗恩回结肠病的女性病例，该患者在直肠结肠切除术后47年，回肠造口处被诊断出原发性腺癌并伴有肝转移，同时对相关文献进行综述。
