Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China.
Biomater Sci. 2023 Feb 14;11(4):1137-1152. doi: 10.1039/d2bm01593e.
tumor vaccination has aroused tremendous interest with its capability for eliciting strong and systemic antitumor immune responses. Unlike traditional cancer vaccines, tumor vaccination avoids the laborious process of tumor antigen identification and can modulate tumor immunosuppressive microenvironment at the same time. In recent years, bacteria have been used as both efficient tumor-targeted delivery vehicles and potent adjuvants. Regarding the rapid development in this area, in this review, we summarize recent advances in the application of bacteria for cancer vaccination. We illustrate the mechanisms of bacteria as both efficient tumor immunogenic cell death inducers and tumor-targeted delivery platforms. Then we comprehensively review the engineering strategies for designing bacteria-based vaccination, including chemical modification, nanotechnology, and genetic engineering. The current dilemma and future directions are discussed at the end of this review.
肿瘤疫苗因其能够诱导强烈的系统性抗肿瘤免疫应答而引起了极大的兴趣。与传统的癌症疫苗不同，肿瘤疫苗避免了费力的肿瘤抗原识别过程，同时可以调节肿瘤免疫抑制微环境。近年来，细菌被用作有效的肿瘤靶向递送载体和有效的佐剂。鉴于该领域的快速发展，在本综述中，我们总结了细菌在癌症疫苗中的应用的最新进展。我们阐述了细菌作为有效的肿瘤免疫原性细胞死亡诱导剂和肿瘤靶向递送平台的作用机制。然后，我们全面回顾了基于细菌的疫苗设计的工程策略，包括化学修饰、纳米技术和遗传工程。最后讨论了当前的困境和未来的发展方向。
