Department of Central Laboratory, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute. No. 44, Shenyang, China.
Department of Biobank, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute. No. 44, Shenyang, China.
Front Cell Infect Microbiol. 2023 May 2;13:1164654. doi: 10.3389/fcimb.2023.1164654. eCollection 2023.
Malignant gliomas occur more often in adults and may affect any part of the central nervous system (CNS). Although their results could be better, surgical excision, postoperative radiation and chemotherapy, and electric field therapy are today's mainstays of glioma care. However, bacteria can also exert anti-tumor effects mechanisms such as immune regulation and bacterial toxins to promote apoptosis, inhibit angiogenesis, and rely on their natural characteristics to target the tumor microenvironment of hypoxia, low pH, high permeability, and immunosuppression. Tumor-targeted bacteria expressing anticancer medications will go to the cancer site, colonize the tumor, and then produce the therapeutic chemicals that kill the cancer cells. Targeting bacteria in cancer treatment has promising prospects. Rapid advances have been made in the study of bacterial treatment of tumors, including using bacterial outer membrane vesicles to load chemotherapy drugs or combine with nanomaterials to fight tumors, as well as the emergence of bacteria combined with chemotherapy, radiotherapy, and photothermal/photodynamic therapy. In this study, we look back at the previous years of research on bacteria-mediated glioma treatment and move forward to where we think it is headed.
恶性脑胶质瘤更常发生于成年人，并且可能影响中枢神经系统（CNS）的任何部位。尽管它们的结果可能更好，但手术切除、术后放疗和化疗以及电场治疗是目前治疗脑胶质瘤的主要方法。然而，细菌也可以发挥抗肿瘤作用，例如通过免疫调节和细菌毒素促进细胞凋亡、抑制血管生成，并利用其天然特性靶向缺氧、低 pH 值、高通透性和免疫抑制的肿瘤微环境。表达抗癌药物的肿瘤靶向细菌将前往癌症部位，定植于肿瘤，然后产生杀死癌细胞的治疗性化学物质。在癌症治疗中靶向细菌具有广阔的前景。在细菌治疗肿瘤的研究中取得了快速进展，包括利用细菌外膜囊泡装载化疗药物或与纳米材料结合以抗肿瘤，以及细菌与化疗、放疗和光热/光动力治疗相结合的出现。在本研究中，我们回顾了前几年关于细菌介导的脑胶质瘤治疗的研究，并展望了未来的发展方向。
