Hu Miaomiao, Li Mengli, Li Chenchen, Miao Ming, Zhang Tao
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, Jiangsu 214122, China.
J Agric Food Chem. 2023 Jan 18;71(2):994-1001. doi: 10.1021/acs.jafc.2c05734. Epub 2023 Jan 5.
The primary active components of breast milk are human milk oligosaccharides (HMOs). HMOs provide many benefits to infants, including regulating their metabolism, immune system, and brain development. Recent studies have emphasized that HMOs act as prebiotics by the metabolism of intestinal microorganisms to produce short-chain fatty acids, which are crucial for infant development. In addition, HMOs with different structural characteristics can form different microbial compositions. HMOs-induced predominant microbes, including , , , and , and their metabolites demonstrated pertinent health-promoting properties. Meanwhile, HMOs could also directly reduce the occurrence of diseases through the effects of preventing pathogen infection. In this review, we address the probable function of HMOs inside the HMOs-gut microbiota-infant network, by describing the physiological functions of HMOs and the implications of diet on the HMOs-gut microbiota-infant network.
母乳的主要活性成分是母乳低聚糖（HMOs）。HMOs对婴儿有诸多益处，包括调节其新陈代谢、免疫系统和大脑发育。最近的研究强调，HMOs通过肠道微生物的代谢作用充当益生元，产生对婴儿发育至关重要的短链脂肪酸。此外，具有不同结构特征的HMOs可形成不同的微生物组成。HMOs诱导的优势微生物，包括[此处原文缺失具体微生物名称]及其代谢产物表现出相关的健康促进特性。同时，HMOs还可通过预防病原体感染的作用直接降低疾病的发生率。在本综述中，我们通过描述HMOs的生理功能以及饮食对HMOs-肠道微生物群-婴儿网络的影响，探讨了HMOs在HMOs-肠道微生物群-婴儿网络中的可能功能。
