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新型混合四极杆-多反射飞行时间质谱系统。

Novel Hybrid Quadrupole-Multireflecting Time-of-Flight Mass Spectrometry System.

机构信息

Waters Corporation, Stamford Avenue, Altrincham Road, Wilmslow, Cheshire, U.K.SK9 4AX.

MSC-CG Ltd, Novi Bulevar A5, Bar85000, Montenegro.

出版信息

J Am Soc Mass Spectrom. 2023 Feb 1;34(2):264-272. doi: 10.1021/jasms.2c00281. Epub 2023 Jan 5.

DOI:10.1021/jasms.2c00281
PMID:36603847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9896552/
Abstract

A novel mass spectrometry system is described here comprising a quadrupole-multireflecting time-of-flight design. The new multireflecting time-of-flight analyzer has an effective path length of 48 m and employs planar, gridless ion mirrors providing fourth-order energy focusing resulting in resolving power over 200 000 fwhm and sub-ppm mass accuracy. We show how these attributes are maintained with relatively fast acquisition speeds, setting the system apart from other high resolution mass spectrometers. We have integrated this new system into both liquid chromatography-mass spectrometry and mass spectrometry imaging workflows to demonstrate how the instrument characteristics are of benefit to these applications.

摘要

这里描述了一种新型的质谱系统，它由四极杆多反射飞行时间设计组成。新的多反射飞行时间分析仪的有效路径长度为 48 米，采用平面、无栅离子镜，提供四阶能量聚焦，分辨率超过 200000 fwhm，质量精度优于 ppm。我们展示了如何在相对较快的采集速度下保持这些属性，使该系统有别于其他高分辨率质谱仪。我们已经将这个新系统集成到液相色谱-质谱和质谱成像工作流程中，以展示仪器特性如何有益于这些应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/f8f1fe1db125/js2c00281_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/3e74c929f0fb/js2c00281_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/1dda754a6a71/js2c00281_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/9359e5daaadd/js2c00281_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/cfda8592c2d0/js2c00281_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/2dbc437db867/js2c00281_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/f8f1fe1db125/js2c00281_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/3e74c929f0fb/js2c00281_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/1dda754a6a71/js2c00281_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/9359e5daaadd/js2c00281_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/cfda8592c2d0/js2c00281_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/2dbc437db867/js2c00281_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3580/9896552/f8f1fe1db125/js2c00281_0006.jpg

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