Yan Kun, Wan Yekai, Xu Feiyang, Lu Jing, Yang Chenguang, Li Xiufang, Lu Zhentan, Wang Xungai, Wang Dong
Hubei Key Laboratory of Advanced Textile Materials & Application, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials &Application, Key Laboratory of Textile Fiber & Product, Ministry of Education, Wuhan Textile University, Wuhan 430200, China.
School of Fashion and Textile, Hong Kong Polytechnic University, Hong Kong, China.
Carbohydr Polym. 2023 Feb 15;302:120427. doi: 10.1016/j.carbpol.2022.120427. Epub 2022 Dec 5.
Herein, a polysaccharide-based fluorescent hydrogel with multi-responsiveness simply implemented by concurrent effects of ionic crosslinking/rehydration processes is presented. Specifically, the alginate and carboxymethyl chitosan are chosen to prepare the interpenetrating polymer matrix while a pair of metal cations has been selectively sequentially integrated to alter hydrogel mechanical and fluorescent properties. Experimental results indicate the hydrogels show tunable fluorescent emission in response to multiple cations and pH conditions, and display a reversible "ON/OFF" fluorescent response to M/ethylenediaminetetraacetic acid. Moreover, this synergistic ionic crosslinking strategy is proved to be highly effective in preparing multifunctional metallohydrogels possessing robust/anisotropic mechanical properties, typical shape memory and cation/pH-responsive fluorescence performance, and a proof-of-application for bacterial detection and sterilization has also been demonstrated. Therefore, we believe this study would provide new insights into multifunctional luminescent hydrogels for advanced biomedical systems.
在此，我们展示了一种基于多糖的具有多重响应性的荧光水凝胶，它通过离子交联/再水化过程的协同效应简单实现。具体而言，选择藻酸盐和羧甲基壳聚糖来制备互穿聚合物基质，同时选择性地依次整合一对金属阳离子以改变水凝胶的力学和荧光性质。实验结果表明，水凝胶在多种阳离子和pH条件下表现出可调谐的荧光发射，并对M/乙二胺四乙酸显示出可逆的“开/关”荧光响应。此外，这种协同离子交联策略被证明在制备具有强大/各向异性力学性能、典型形状记忆以及阳离子/pH响应荧光性能的多功能金属水凝胶方面非常有效，并且还展示了其在细菌检测和杀菌方面的应用证明。因此，我们相信这项研究将为先进生物医学系统中的多功能发光水凝胶提供新的见解。
