Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, Palestine.
BMC Complement Med Ther. 2023 Jan 5;23(1):3. doi: 10.1186/s12906-022-03830-8.
The use of conventional medical therapies has proven to have many setbacks and safety concerns that need further improvement. However, herbal medicine has been used for over 2000 years, and many studies have proven the use of herbs to be effective and safe. This article discussed the efficacy of different herbal products used in the management of obesity. To evaluate the efficacy of seven herbal-based weight loss products currently available on the Palestinian market, using in vitro assays to screen for antioxidants, anti-amylase, and anti-lipase effects for each product.
Pancreatic lipase and salivary amylase inhibitory activities, as well as antioxidant analysis, were tested in vitro on a variety of herbal products. Then the IC was measured for each test.
The anti-lipase assay results, IC values in (μg/mL) of each of the seven products (Product A, product B, product C, product D, product E, product F, and product G) were 114.78, 532.1, 60.18, 53.33, 244.9, 38.9, and 48.97, respectively. The IC value for orlistat (Reference) was 12.3 μg/ml. On the other hand, the IC value for alpha amylase inhibition of the seven products (Product A, product B, product C, product D, product E, product F, and product F) were 345.93, 13,803.84 (Inactive), 73.79, 130.91, 165.95, 28.18, and 33.11 μg/ml respectively, while acarbose (Reference) was 23.38 μg/ml. The antioxidant activity (IC values) for the seven products (Product A, product B, product C, product D, product E, product F, and product F) were 1258.92, 707.94, 79.43, 186.20, 164.81, 17.53, and 10.47 μg/ml respectively. While the IC value for Trolox was 2.70 μg/ml.
It can be concluded that the seven products showed varied anti-lipase, anti-amylase, and antioxidant effects. However, products F and G showed superiority in all categories.
常规医学疗法已被证明存在许多弊端和安全隐患，需要进一步改进。然而，草药已经使用了 2000 多年，许多研究已经证明草药的使用是有效和安全的。本文讨论了不同的草药产品在肥胖管理中的功效。为了评估目前在巴勒斯坦市场上销售的七种基于草药的减肥产品的功效，我们使用体外分析方法来筛选每种产品的抗氧化剂、抗淀粉酶和抗脂肪酶作用。
在各种草药产品上进行了胰腺脂肪酶和唾液淀粉酶抑制活性以及抗氧化分析的体外测试，然后测量了每种测试的 IC 值。
七种产品（产品 A、产品 B、产品 C、产品 D、产品 E、产品 F 和产品 G）的抗脂肪酶测定结果的 IC 值（μg/mL）分别为 114.78、532.1、60.18、53.33、244.9、38.9 和 48.97，奥利司他（参考）的 IC 值为 12.3μg/ml。另一方面，七种产品（产品 A、产品 B、产品 C、产品 D、产品 E、产品 F 和产品 G）对α-淀粉酶抑制的 IC 值分别为 345.93、13803.84（无活性）、73.79、130.91、165.95、28.18 和 33.11μg/ml，阿卡波糖（参考）的 IC 值为 23.38μg/ml。七种产品（产品 A、产品 B、产品 C、产品 D、产品 E、产品 F 和产品 G）的抗氧化活性（IC 值）分别为 1258.92、707.94、79.43、186.20、164.81、17.53 和 10.47μg/ml，Trolox 的 IC 值为 2.70μg/ml。
可以得出结论，这七种产品表现出不同的抗脂肪酶、抗淀粉酶和抗氧化作用。然而，产品 F 和 G 在所有类别中都表现出优势。
