Department of Medical Services and Techniques, School of Vocational Healh Care Services, Recep Tayyip Erdogan University, 53100 Rize, Turkey.
Department of Biochemistry, Recep Tayyip Erdogan University, 53100 Rize, Turkey.
Medicina (Kaunas). 2024 Sep 25;60(10):1568. doi: 10.3390/medicina60101568.
Obesity and related disorders are an increasing global health problem. Achieving and maintaining long-term weight loss through lifestyle changes and/or pharmacological interventions have not met expectations. Dietary supplements and alternative treatments have also shown limited effectiveness in this regard. The consumption of green tea in general has been shown to benefit obese patients, with effects attributed to caffeine, catechins, polyphenols and other components. However, the potential of white tea to prevent and treat the negative effects of obesity has not been addressed so far. In this study, the effect of white tea (WT) consumption in obese individuals was anthropometrically and biochemically investigated. : Based on anthropometric and biochemical assessments, the patients were assigned to the control, orlistat, metformin and WT groups. Patients were given a diet and exercise program and one of either orlistat, metformin or WT for 12 weeks. At the end of the 12th week, the anthropometric and biochemical measurements were reassessed. Body weight, waist circumference and BMI parameters decreased significantly in all groups. TNF-α, IL-6, IL-1β and MMP-9 levels decreased significantly in the WT group. In addition, contrary to a significant elevation in HDL-C, the serum cholesterol, LDL-C and TG levels decreased significantly. Furthermore, leptin, ghrelin and asprosin levels decreased significantly. Serum glucose levels decreased significantly in all groups except for the control. In the WT group, while there was a significant decrease in the levels of serum PL MDA and 8-OHdG, the opposite was true for GSH. The oral consumption of WT, its availability and its potency in obesity treatment and prevention pave the way for further delineation of the mechanisms of actions of its bioactive compounds at the cellular and endocrinological levels.
肥胖及相关疾病是日益严重的全球性健康问题。通过生活方式改变和/或药物干预来实现并维持长期体重减轻的目标尚未达到预期。在这方面，膳食补充剂和替代疗法的效果也有限。一般来说，绿茶的消费已被证明对肥胖患者有益，其效果归因于咖啡因、儿茶素、多酚和其他成分。然而，白茶预防和治疗肥胖负面影响的潜力尚未得到解决。在这项研究中，研究了白茶（WT）消费对肥胖个体的影响。
基于人体测量学和生物化学评估，将患者分为对照组、奥利司他组、二甲双胍组和 WT 组。患者接受饮食和运动方案，并给予奥利司他、二甲双胍或 WT 中的一种，持续 12 周。在第 12 周结束时，重新评估人体测量学和生物化学测量。
所有组的体重、腰围和 BMI 参数均显著降低。WT 组 TNF-α、IL-6、IL-1β 和 MMP-9 水平显著降低。此外，与 HDL-C 显著升高相反，血清胆固醇、LDL-C 和 TG 水平显著降低。此外，瘦素、胃饥饿素和 asprosin 水平显著降低。除对照组外，所有组的血清葡萄糖水平均显著降低。在 WT 组，虽然血清 PL MDA 和 8-OHdG 水平显著降低，但 GSH 水平却相反。
WT 的口服摄入、其可用性及其在肥胖治疗和预防中的功效为进一步阐明其生物活性化合物在细胞和内分泌水平上的作用机制铺平了道路。
