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美国普通人群中挥发性有机化合物暴露与肥胖之间的关联分析:一项来自美国国家健康与营养检查调查(NHANES)项目的横断面研究。

The association analysis between exposure to volatile organic chemicals and obesity in the general USA population: A cross-sectional study from NHANES program.

作者信息

Lei Ting, Qian Hu, Yang Junxiao, Hu Yihe

机构信息

Department of Orthopedic Surgery, Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, 410008, China.

Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

出版信息

Chemosphere. 2023 Feb;315:137738. doi: 10.1016/j.chemosphere.2023.137738. Epub 2023 Jan 3.

Abstract

BACKGROUND

Increasing evidence have been provided that the exposure to environment pollutants was associated obesity, while whether the exposure to volatile organic chemicals (VOC) was associated with obesity or abdominal obesity is yet to be clarified.

METHOD

A cross-sectional study using data from the 6 survey cycles (2005-2006, 2011-2018, 2017-2020) of NHANES program was performed. Obesity and abdominal obesity were identified as a BMI >30 and a waist circumference >102 cm for men or >88 cm for women respectively. The quantile logistic regression method was used to analyze the association between VOC metabolites (VOCs) in urine and obesity, and the quantile regression method was used for the association analysis between VOCs in urine and BMI, as well as waist circumference.

RESULTS

A total of 17 524 participants (4965 obesity, 7317 abdominal obesity) were included, and participants in the obesity or abdominal obesity groups showed higher VOCs in urine than that in the control group. The CEMA was identified as the risk factor for obesity and abdominal obesity in all the 4 models, and its detected OR for obesity in the Q2 to Q4 of model 3 was 1.169 (Q2, p < 0.05), 1.306 (Q3, p < 0.001) and 1.217 (Q4, p < 0.01) respectively. And its OR for abdominal obesity in the Q2 to Q4 of model 3 was 1.222 (Q2, p < 0.01), 1.448 (Q3, p < 0.001) and 1.208 (Q4, p < 0.05) respectively. A significantly positive association between CEMA and BMI, as well as waist circumference, was also detected.

CONCLUSION

In this study, we found that the exposure to VOC (Acrolein, Acrylamide, Acrylonitrile, 1,3-Butadiene, Crotonaldehyde, Cyanide, N,N-Dimethylformamide, Ethylbenzene, styrene, Propylene oxide, Toluene and Xylene) was significantly associated with obesity or abdominal obesity. And also, more prospective studies and related experimental researches should be carried out to further demonstrate the conclusion of this study.

摘要

背景

越来越多的证据表明,接触环境污染物与肥胖有关,而接触挥发性有机化合物(VOC)是否与肥胖或腹型肥胖有关尚待阐明。

方法

采用美国国家健康与营养检查调查(NHANES)项目6个调查周期(2005 - 2006年、2011 - 2018年、2017 - 2020年)的数据进行横断面研究。肥胖和腹型肥胖分别定义为男性体重指数(BMI)>30且腰围>102厘米,女性BMI>30且腰围>88厘米。采用分位数逻辑回归方法分析尿中VOC代谢物(VOCs)与肥胖之间的关联,采用分位数回归方法分析尿中VOCs与BMI以及腰围之间的关联。

结果

共纳入17524名参与者(4965例肥胖者,7317例腹型肥胖者),肥胖或腹型肥胖组参与者尿中的VOCs水平高于对照组。在所有4个模型中,CEMA被确定为肥胖和腹型肥胖的危险因素,其在模型3的Q2至Q4中肥胖的检测比值比(OR)分别为1.169(Q2,p<0.05)、1.306(Q3,p<0.001)和1.217(Q4,p<0.01)。其在模型3的Q2至Q4中腹型肥胖的OR分别为1.222(Q2,p<0.01)、1.448(Q3,p<0.001)和1.208(Q4,p<0.05)。还检测到CEMA与BMI以及腰围之间存在显著正相关。

结论

在本研究中,我们发现接触VOC(丙烯醛、丙烯酰胺、丙烯腈、1,3 - 丁二烯、巴豆醛、氰化物、N,N - 二甲基甲酰胺、乙苯、苯乙烯、环氧丙烷、甲苯和二甲苯)与肥胖或腹型肥胖显著相关。此外,应开展更多前瞻性研究和相关实验研究以进一步证实本研究结论。

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