Department of Ophthalmology, Konyang University College of Medicine, #1643 Gwanjeo-dong, Seo-gu, Daejeon, Republic of Korea.
Sci Rep. 2023 Jan 6;13(1):268. doi: 10.1038/s41598-023-27529-z.
To investigate the impact of the combination of type 2 diabetes (DM) and high myopia on inner retinal layer thickness of the macular area. The patients were divided into four groups: control (group 1), patients with DM without high myopia (group 2), patients with high myopia without DM (group 3), and patients with DM and high myopia (group 4). Ganglion cell complex (GCC) thickness was compared among the groups. Linear regression analysis was performed to identify factors associated with GCC thickness. A total of 194 eyes were enrolled: 59 in group 1, 52 in group 2, 49 in group 3, and 34 in group 4. The average parafovea GCC thicknesses were 113.9 ± 10.4, 112.4 ± 11.2, 112.2 ± 7.8, and 102.6 ± 15.1 μm (P < 0.001), and the average perifovea GCC thicknesses were 104.8 ± 13.2, 103.5 ± 10.8, 103.6 ± 8.8, and 93.9 ± 15.5 μm in groups 1, 2, 3 and 4, respectively (P = 0.001). In multivariate analyses, age (β = - 0.20, P = 0.007), DM duration (β = - 0.34, P = 0.023), and axial length (β = - 1.64, P < 0.001) were significantly associated with parafoveal GCC thickness. The GCC was significantly thinner when high myopia and DM were combined, compared to either condition alone. Additionally, age, DM duration, and axial length were significant factors associated with GCC thickness. The combination of mechanical stretching and neurodegeneration would accelerate neural damage to the retina, resulting in greater inner retinal layer thinning.
为了研究 2 型糖尿病（DM）和高度近视合并对黄斑区内层视网膜厚度的影响。将患者分为四组：对照组（第 1 组）、无高度近视的 DM 患者（第 2 组）、无 DM 的高度近视患者（第 3 组）和 DM 和高度近视患者（第 4 组）。比较各组的神经节细胞复合体（GCC）厚度。进行线性回归分析以确定与 GCC 厚度相关的因素。共纳入 194 只眼：第 1 组 59 只眼，第 2 组 52 只眼，第 3 组 49 只眼，第 4 组 34 只眼。平均旁中心 GCC 厚度分别为 113.9 ± 10.4μm、112.4 ± 11.2μm、112.2 ± 7.8μm 和 102.6 ± 15.1μm（P<0.001），平均中心凹 GCC 厚度分别为 104.8 ± 13.2μm、103.5 ± 10.8μm、103.6 ± 8.8μm 和 93.9 ± 15.5μm 在第 1、2、3 和 4 组中，分别（P=0.001）。多元分析中，年龄（β=-0.20，P=0.007）、DM 病程（β=-0.34，P=0.023）和眼轴长度（β=-1.64，P<0.001）与旁中心 GCC 厚度显著相关。与任何一种情况相比，高度近视和 DM 合并时 GCC 明显变薄。此外，年龄、DM 病程和眼轴长度是与 GCC 厚度相关的重要因素。机械拉伸和神经退行性变的结合会加速对视网膜的神经损伤，导致内层视网膜更薄。
