Svendsen K H, Kuller L H, Martin M J, Ockene J K
Coordinating Centers for Biometric Research, U. of Minnesota, Minneapolis 55414.
Am J Epidemiol. 1987 Nov;126(5):783-95. doi: 10.1093/oxfordjournals.aje.a114715.
The Multiple Risk Factor Intervention Trial (MRFIT), conducted in 1973-1982, provided a unique opportunity to study the effect of passive smoking on men whose wives smoke. MRFIT participants who reported at entry that they had never smoked tobacco products were classified according to the smoking status of their wives. Men with wives who smoked had similar mean levels of serum thiocyanate (54.3 vs. 53.9 mumol/liter, p = 0.83) but higher mean levels of expired carbon monoxide (7.7 vs. 7.1 ppm, p = 0.001). Lower levels of pulmonary function (by maximum forced expiratory volume in one second) were also observed in these men (3,493.1 vs. 3,591.9 ml, p = 0.04). The relative risks, for men whose wives smoked compared with men whose wives did not smoke, for the endpoints coronary heart disease death, fatal or nonfatal coronary heart disease event, and death from any cause were 2.11 (p = 0.19, 95% confidence interval (CI) 0.69-6.46), 1.48 (p = 0.13, 95% CI 0.89-2.47), and 1.96 (p = 0.08, 95% CI 0.93-4.11), respectively. When smokers who quit prior to entry were included in the analyses, the relative risks, for men whose wives smoked compared with men whose wives did not smoke, for the above endpoints were 1.45 (p = 0.25, 95% CI 0.77-2.73), 1.19 (p = 0.29, 95% CI 0.85-1.65), and 1.72 (p = 0.01, 95% CI 1.12-2.64), respectively. These relative risk estimates did not change appreciably after adjusting for other baseline risk factors. The results suggest that passive exposure to cigarette smoke may have a deleterious impact on the health of nonsmokers and that nonsmokers may be at an increased risk of death through passive exposure to cigarette smoke.
1973年至1982年开展的多重危险因素干预试验（MRFIT）提供了一个独特的机会，来研究被动吸烟对妻子吸烟的男性的影响。MRFIT的参与者在入组时报告自己从不吸烟，他们根据妻子的吸烟状况进行分类。妻子吸烟的男性血清硫氰酸盐的平均水平相似（54.3对53.9微摩尔/升，p = 0.83），但呼出一氧化碳的平均水平更高（7.7对7.1 ppm，p = 0.001）。在这些男性中还观察到肺功能水平较低（以一秒用力呼气量衡量）（3493.1对3591.9毫升，p = 0.04）。与妻子不吸烟的男性相比，妻子吸烟的男性在冠心病死亡、致命或非致命冠心病事件以及任何原因导致的死亡这些终点事件上的相对风险分别为2.11（p = 0.19，95%置信区间（CI）0.69 - 6.46）、1.48（p = 0.13，95% CI 0.89 - 2.47）和1.96（p = 0.08，95% CI 0.93 - 4.11）。当将入组前戒烟的吸烟者纳入分析时，与妻子不吸烟的男性相比，妻子吸烟的男性在上述终点事件上的相对风险分别为1.45（p = 0.25, 95% CI 0.77 - 2.73）、1.19（p = 0.29, 95% CI 0.85 - 1.65）和1.72（p = 0.01, 95% CI 1.12 - 2.64）。在对其他基线风险因素进行调整后，这些相对风险估计值没有明显变化。结果表明，被动接触香烟烟雾可能对不吸烟者的健康产生有害影响，并且不吸烟者可能因被动接触香烟烟雾而死亡风险增加。
