Garland C, Barrett-Connor E, Suarez L, Criqui M H, Wingard D L
Am J Epidemiol. 1985 May;121(5):645-50. doi: 10.1093/aje/121.5.645.
The mortality attributable to ischemic heart disease as a result of cigarette smoking is greater of a community of older adults in southern California, the authors tested the hypothesis that nonsmoking women exposed to their husband's cigarette smoke would have an elevated risk of fatal ischemic heart disease. Married women aged 50-79 years who had never smoked cigarettes (n = 695) were classified according to the husband's self-reported smoking status at entry into the study: never, former, or current smoker. After 10 years, nonsmoking wives of current or former cigarette smokers had a higher total (p less than or equal to 0.05) and age-adjusted (p less than or equal to 0.10) death rate from ischemic heart disease than women whose husbands never smoked. After adjustment for differences in risk factors for heart disease, the relative risk for death from ischemic heart disease in nonsmoking women married to current or former cigarette smokers was 14.9 (p less than or equal to 0.10). These data are compatible with the hypothesis that passive cigarette smoking carries an excess risk of fatal ischemic heart disease.
由于吸烟导致的缺血性心脏病死亡率在南加州的老年人群体中更高，作者检验了这样一个假设：暴露于丈夫吸烟环境中的不吸烟女性患致命性缺血性心脏病的风险会升高。研究纳入了695名年龄在50 - 79岁且从未吸烟的已婚女性，根据其丈夫在研究开始时自我报告的吸烟状况进行分类：从不吸烟、曾经吸烟或目前吸烟。10年后，丈夫目前或曾经吸烟的不吸烟妻子，其缺血性心脏病的总死亡率（p≤0.05）和年龄调整死亡率（p≤0.10）高于丈夫从不吸烟的女性。在对心脏病风险因素的差异进行调整后，与目前或曾经吸烟的男性结婚的不吸烟女性死于缺血性心脏病的相对风险为14.9（p≤0.10）。这些数据与被动吸烟会带来致命性缺血性心脏病额外风险这一假设相符。
