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基于 L. 的绿色合成氧化锌纳米粒子具有抗人冠状病毒 229-E 的潜在抗病毒活性。

Green Synthesized Zinc Oxide Nanoparticles Based on L. of Potential Antiviral Activity against Human Corona 229-E Virus.

机构信息

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Giza 11562, Egypt.

Trees Research Department, Horticulture Research Institute, Agriculture Research Center, Giza 12619, Egypt.

出版信息

Molecules. 2022 Dec 28;28(1):266. doi: 10.3390/molecules28010266.

DOI:10.3390/molecules28010266
PMID:36615461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9822259/
Abstract

SARS-CoV-2 has caused more than 596 million infections and 6 million fatalities globally. Looking for urgent medication for prevention, treatment, and rehabilitation is obligatory. Plant extracts and green synthesized nanoparticles have numerous biological activities, including antiviral activity. HPLC analysis of L. leaf extract showed that catechin, ferulic acid, chlorogenic acid, and syringic acid were the most major compounds, with concentrations of 1425.16, 1004.68, 207.46, and 158.95 µg/g, respectively. Zinc nanoparticles were biosynthesized using zinc acetate and extract. TEM analysis revealed that the particle size of ZnO-NPs varied between 3.406 and 4.857 nm. An XRD study showed the existence of hexagonal crystals of ZnO-NPs with an average size of 12.11 nm. Both ZnO-NPs (IC = 7.01 and CC = 145.77) and L. extract (IC = 61.15 and CC = 145.87 µg/mL) showed antiviral activity against HCOV-229E, but their combination (IC = 2.41 and CC = 179.23) showed higher activity than both. Molecular docking was used to investigate the affinity of some metabolites against the HCOV-229E main protease. Chlorogenic acid, solanidine, and catchin showed high affinity (-7.13, -6.95, and -6.52), compared to the ligand MDP (-5.66 Kcal/mol). extract and ZnO-NPs combination should be subjected to further studies to be used as an antiviral drug.

摘要

SARS-CoV-2 已在全球范围内导致超过 5.96 亿例感染和 600 万人死亡。寻找预防、治疗和康复的紧急药物是必要的。植物提取物和绿色合成的纳米颗粒具有多种生物活性，包括抗病毒活性。HPLC 分析 L. 叶提取物表明，表儿茶素、阿魏酸、绿原酸和丁香酸是最主要的化合物，浓度分别为 1425.16、1004.68、207.46 和 158.95 µg/g。锌纳米颗粒是使用醋酸锌和 提取物生物合成的。TEM 分析表明，ZnO-NPs 的粒径在 3.406 到 4.857nm 之间。XRD 研究表明 ZnO-NPs 存在六方晶体，平均粒径为 12.11nm。ZnO-NPs（IC = 7.01 和 CC = 145.77）和 L. 提取物（IC = 61.15 和 CC = 145.87 µg/mL）均显示出对 HCOV-229E 的抗病毒活性，但两者的组合（IC = 2.41 和 CC = 179.23）显示出比两者更高的活性。分子对接用于研究一些代谢物对 HCOV-229E 主要蛋白酶的亲和力。绿原酸、茄啶和儿茶素显示出高亲和力（-7.13、-6.95 和-6.52），与配体 MDP（-5.66 Kcal/mol）相比。应进一步研究 提取物和 ZnO-NPs 组合，将其用作抗病毒药物。

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