Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021 Bucharest, Romania.
Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 060042 Bucharest, Romania.
Sensors (Basel). 2022 Dec 28;23(1):314. doi: 10.3390/s23010314.
Since the determination of the high toxicity of bisphenol A, alternative structures for bisphenols have been synthesized, resulting in bisphenols C, E, F, S, and Z. These bisphenols have replaced bisphenol A in plastic bottles, toys, and cans used for preserving food. Later, the toxicity and negative effects of all of these bisphenols on people's health were proven. Therefore, there is a need for a fast ultrasensitive screening method that is able to detect the presence of these bisphenols in any condition directly from food samples. This paper presented a disposable device based on the utilization of a 2D disposable paper stochastic sensor for the fast ultrasensitive screening of food samples for bisphenols A, C, E, F, S, and Z. The 2D disposable sensor was obtained by the deposition of graphene and silver nanolayers on paper using cold plasma. Furthermore, the active side of the sensor was modified using 2,3,7,8,12,13,17,18-octaethyl-21H,23H Mn porphyrin. The limits of quantification of these bisphenols were 1 fmol L for bisphenols C and E, 10 fmol L for bisphenols A and F, 10 pmol L for bisphenol S, and 1 pmol L for bisphenol Z. The recoveries of these bisphenols in milk, canned fruits, vegetables, and fish were higher than 99.00% with RSD (%) values lower than 1.50%.
由于双酚 A 的高毒性已被确定，因此已合成了双酚的替代结构，从而产生了双酚 C、E、F、S 和 Z。这些双酚已在用于保存食品的塑料瓶、玩具和罐头中替代了双酚 A。后来，所有这些双酚对人体健康的毒性和负面影响都已得到证实。因此，需要一种快速超灵敏的筛选方法，能够直接从食品样品中检测到这些双酚的存在。本文提出了一种基于二维（2D）一次性纸随机传感器的一次性装置，用于快速超灵敏筛选食品样品中的双酚 A、C、E、F、S 和 Z。2D 一次性传感器是通过冷等离子体在纸上沉积石墨烯和银纳米层获得的。此外，传感器的活性侧使用 2,3,7,8,12,13,17,18-八乙基-21H，23H Mn 卟啉进行了修饰。这些双酚的定量限为双酚 C 和 E 为 1 fmol L，双酚 A 和 F 为 10 fmol L，双酚 S 为 10 pmol L，双酚 Z 为 1 pmol L。这些双酚在牛奶、罐装水果、蔬菜和鱼类中的回收率均高于 99.00%，相对标准偏差（RSD）（%）值低于 1.50%。
