按性别、年份、国内生产总值和大洲划分的COVID-19住院老年患者全球病死率：一项系统评价、荟萃分析和元回归分析

The global case fatality rate due to COVID-19 in hospitalized elderly patients by sex, year, gross domestic product, and continent: A systematic review, meta-analysis, and meta-regression.

作者信息

Esmaeili Elham Davtalab, Azizi Hosein, Sarbazi Ehsan, Khodamoradi Farzad

机构信息

Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

New Microbes New Infect. 2023 Jan;51:101079. doi: 10.1016/j.nmni.2022.101079. Epub 2023 Jan 4.

DOI:10.1016/j.nmni.2022.101079

PMID:36618974

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9811917/

Abstract

BACKGROUND

Although elderly people are at a huge risk of mortality due to COVID-19, the Case Fatality Rate (CFR) in hospitalized elderly patients is poorly investigated. This meta-analysis and meta-regression aimed to generate pooled CFR due to COVID-19 in hospitalized elderly patients by sex, Gross Domestic Product (GDP), year, and continent and also to explain the potential source of the heterogeneity and variations in the pooled estimation of COVID-19 CFR.

METHODS

We systematically searched PubMed, Scopus, Web of Science, CINAHL, and Embase up to 31 July 2022. Eligibility assessment of records was performed independently in a blinded, standardized way by two reviewers. Meta-analysis and Meta-regression analysis were carried out to estimate pooled CFR and the potential sources of the heterogeneity.

RESULTS

The study included 5683 confirmed hospitalized elderly COVID-19 patients, 1809 deaths, and 19 original articles from 10 countries. The pooled estimate of the overall CFR, and by male and female sexes were 29%, 34%, and 24%, respectively. We found CFR was decreased by increasing female sex proportion, GDP, and year of publication. Multivariate meta-regression analysis indicated that the age and sex of patients, continent, GDP, and year of the publication together explained the majority of the heterogeneity and variations in the pooled estimate of the hospitalized elderly COVID-19 CFR.

CONCLUSIONS

This review provided reliable pooled CFR measures for hospitalized elderly patients with COVID-19. Although COVID-19 fatality has decreased in hospitalized elderly patients over time, it is still high in hospitalized elderly patients and needs advanced treatment support.

摘要

背景

尽管老年人因新冠病毒病（COVID-19）面临巨大的死亡风险，但住院老年患者的病死率（CFR）却鲜有研究。本荟萃分析和荟萃回归旨在按性别、国内生产总值（GDP）、年份和大洲生成住院老年患者因COVID-19导致的合并CFR，并解释COVID-19 CFR合并估计中异质性和变异性的潜在来源。

方法

我们系统检索了截至2022年7月31日的PubMed、Scopus、科学引文索引、护理学与健康领域数据库（CINAHL）和Embase。两名评审员以盲法、标准化方式独立进行记录的资格评估。进行荟萃分析和荟萃回归分析以估计合并CFR及异质性的潜在来源。

结果

该研究纳入了来自10个国家的5683例确诊住院的老年COVID-19患者、1809例死亡病例以及19篇原始文章。总体CFR的合并估计值，以及男性和女性的合并估计值分别为29%、34%和24%。我们发现CFR随着女性比例、GDP和发表年份的增加而降低。多变量荟萃回归分析表明，患者的年龄和性别、大洲、GDP以及发表年份共同解释了住院老年COVID-19患者CFR合并估计中大部分的异质性和变异性。