The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Department of Aerospace Medicine, Fourth Military Medical University, Xi'an, China.
PeerJ. 2023 Jan 4;11:e14702. doi: 10.7717/peerj.14702. eCollection 2023.
The effect of fetal oval foramen restriction and premature contraction of the arterial catheter for the right heart function of fetuses and infants was studied by evaluating the right and left ventricular (RV/LV) ratios, the tricuspid annular plane systolic excursion (TAPSE) value, and the Tei index of right heart function parameters.
This study was approved by the Ethics Committee of First Affiliated Hospital of Hebei North University (K20190116). We collected 257 fetuses between March 2020 and December 2021. Among these, 98 fetuses that did not have any heart abnormalities were assigned to group A, 91 fetuses with restriction of the left and right atrial channels were assigned to group B, and 68 fetuses with premature contraction of the arterial catheter were assigned to group C. The ventricular transverse diameter, the right heart TAPSE value and the Tei index of fetuses in late pregnancy and 90 days after birth were measured in the three groups, and the diagnostic value of each index for the right heart function injury was evaluated. < 0.05 indicates significant.
The P-value of the TAPSE value and Tei index of infants in BC and AC groups and postnatal infants were less than 0.05, which was significant. In the BC group, the RV/LV ratio of fetuses was compared when > 0.05, which was not significant; however, < 0.05 after birth was considered significant. For fetuses and postnatal infants in the BC group, the RV/LV ratio was negatively associated with the TAPSE value. However, it was positively associated with the Tei index; Diagnostic test results. To predict impaired right heart function after birth, TAPSE had low diagnostic value, RV/LV and Tei index had high diagnostic value.
Oval foramen restriction and premature contraction of the arterial catheter may affect the right heart function after birth and be related to the degree of the right heart enlargement. Although TAPSE prediction of the fetal and postnatal right heart function is limited, the RV/LV ratio and the Tei index can be used to predict impaired right heart function after birth.
通过评估右心功能参数的右心室/左心室（RV/LV）比值、三尖瓣环平面收缩期位移（TAPSE）值和右心 Tei 指数，研究胎儿卵圆孔限制和动脉导管收缩对胎儿和婴儿右心功能的影响。
本研究经河北北方学院第一附属医院伦理委员会批准（K20190116）。我们收集了 2020 年 3 月至 2021 年 12 月期间的 257 例胎儿。其中，98 例无心脏异常的胎儿被分为 A 组，91 例左右心房通道受限的胎儿被分为 B 组，68 例动脉导管收缩的胎儿被分为 C 组。在三组中测量晚期妊娠和出生后 90 天胎儿的心室横径、右心 TAPSE 值和 Tei 指数，并评估各指数对右心功能损伤的诊断价值。<0.05 表示差异有统计学意义。
BC 组和 AC 组婴儿以及出生后婴儿的 TAPSE 值和 Tei 指数的 P 值均<0.05，差异有统计学意义。BC 组胎儿 RV/LV 比值比较时>0.05，差异无统计学意义；但出生后<0.05，差异有统计学意义。BC 组胎儿和出生后婴儿的 RV/LV 比值与 TAPSE 值呈负相关，与 Tei 指数呈正相关；诊断试验结果。预测出生后右心功能障碍，TAPSE 诊断价值低，RV/LV 和 Tei 指数诊断价值高。
卵圆孔限制和动脉导管收缩可能影响出生后右心功能，并与右心扩大程度有关。虽然 TAPSE 对胎儿和出生后右心功能的预测有限，但 RV/LV 比值和 Tei 指数可用于预测出生后右心功能障碍。
