Friedrich-Alexander-Universitat Erlangen-Nürnberg, Erlangen, Germany.
Paracelsus Medizinische Privatuniversität, Salzburg, Austria.
Cartilage. 2023 Mar;14(1):39-47. doi: 10.1177/19476035221147677. Epub 2023 Jan 9.
To assess the association of worsening of magnetic resonance imaging (MRI) semi-quantitative (SQ) tissue features with concurrent change in quantitative (Q) cartilage thickness measurements over 24 months within the Foundation for the National Institutes of Health (FNIH) Biomarker Consortium study.
In all, 599 participants were included. SQ assessment included cartilage damage, meniscal extrusion and damage, osteophytes, bone marrow lesions (BMLs), and effusion- and Hoffa-synovitis. Change in medial compartment Q cartilage thickness was stratified by concurrent ipsicompartmental SQ changes. Between-group comparisons were performed using analysis of covariance (ANCOVA) with adjustment for age, sex, and body mass index (BMI). Results were presented as adjusted mean difference.
Knees with any increase in SQ cartilage scores in the medial compartment ( = 268) showed more Q cartilage loss compared to knees that remained stable (mean adjusted difference [MAD] = -0.16 mm, 95% confidence interval [CI]: [-0.19, -0.13] mm). Knees with any increase in meniscal extrusion in the medial compartment (n = 98) showed more Q cartilage loss than knees without (MAD = -0.18 mm, 95% CI: [-0.22, -0.14] mm. Comparable findings were seen for meniscal damage worsening. Regarding BMLs, an increase by one subregion resulted in a MAD of Q cartilage loss of -0.10 mm, 95% CI: [-0.14, -0.06] mm, while this effect almost tripled for change in two or more subregions. Increase in either effusion- and/or Hoffa-synovitis by one grade resulted in a MAD of -0.07 mm, 95% CI: [-0.10, -0.03] mm.
Worsening of SQ cartilage damage, meniscal extrusion and damage, number of subregions affected by BML, maximum size of BMLs and worsening of effusion- and/or Hoffa synovitis is associated with increased Q cartilage loss.
在国立卫生研究院（NIH）生物标志物联盟研究中，评估磁共振成像（MRI）半定量（SQ）组织特征恶化与 24 个月内定量（Q）软骨厚度测量的同时变化之间的相关性。
共纳入 599 名参与者。SQ 评估包括软骨损伤、半月板外突和损伤、骨赘、骨髓病变（BML）、滑液和Hoffa 滑膜炎。内侧间室 Q 软骨厚度的变化按同侧间室 SQ 变化分层。采用协方差分析（ANCOVA）进行组间比较，调整年龄、性别和体重指数（BMI）。结果以调整后的平均差异表示。
内侧间室任何 SQ 软骨评分增加的膝关节（n=268）与保持稳定的膝关节相比，显示出更多的 Q 软骨丢失（平均调整差异[MAD]=-0.16 毫米，95%置信区间[CI]：[-0.19，-0.13]毫米）。内侧间室半月板外突任何增加的膝关节（n=98）比没有增加的膝关节显示出更多的 Q 软骨丢失（MAD=-0.18 毫米，95%CI：[-0.22，-0.14]毫米）。半月板损伤恶化也有类似的发现。关于 BML，一个亚区增加导致 Q 软骨丢失的 MAD 为-0.10 毫米，95%CI：[-0.14，-0.06]毫米，而两个或更多亚区的变化则使这种效果增加近三倍。滑液和/或 Hoffa 滑膜炎增加一个等级导致 Q 软骨丢失的 MAD 为-0.07 毫米，95%CI：[-0.10，-0.03]毫米。
SQ 软骨损伤、半月板外突和损伤、受 BML 影响的亚区数量、BML 的最大大小以及滑液和/或 Hoffa 滑膜炎的恶化与 Q 软骨丢失的增加相关。
