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个人剂量当量 H(0.07) 在 Ga-DOTA-TATE 生产过程中。

Personal dose equivalent H(0.07) during Ga-DOTA-TATE production procedures.

机构信息

Department of Nuclear Physics and Radiation Safety, Faculty of Physics and Applied Informatics, University of Lodz, Pomorska 149/153, 90-236, Lodz, Poland.

出版信息

Radiat Environ Biophys. 2023 Mar;62(1):117-129. doi: 10.1007/s00411-022-01015-y. Epub 2023 Jan 10.

DOI:10.1007/s00411-022-01015-y
PMID:36625834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9950246/
Abstract

This work presents the exposure of hands of the personnel of a nuclear medicine department who prepare and administer Ga-DOTA-TATE. Dosimetry measurements were performed during three 1-week sessions, for nine production procedures. A total of 360 measurements were made by using high-sensitivity MCP-N thermoluminescent detectors. Annealed detectors were and vacuum-packed in foil and then placed on each fingertip of both hands of five radiochemists and four nurses (one detector for one fingertip). The greatest exposure to ionizing radiation was found on the non-dominant left hand of radiochemists and nurses. A maximum H(0.07)/A value of 49.36 ± 4.95 mSv/GBq was registered for radiochemists during the  Ga-DOTA-DATE activity dispensing procedure. For nurses performing the radiopharmaceutical injection procedure, a corresponding maximum value of 1.28 ± 0.13 mSv/GBq was measured, while the mean value for all the nurses was 0.38 mSv/GBq. The dispensing procedure accounted for approximately 60% of the total exposure of radiochemists' fingertips. Based on the results obtained it is recommended that a ring dosimeter should be routinely placed on the middle finger of the non-dominant hand of radiochemists and nurses. Furthermore, it is proposed to systematically train workers in handling open sources of ionizing radiation, with the aim of reducing the required handling time.

摘要

本工作介绍了核医学部门准备和给药 Ga-DOTA-TATE 的人员手部的辐射暴露情况。在三个为期一周的时段中进行了剂量测量，共进行了 9 次生产过程。使用高灵敏度 MCP-N 热释光探测器进行了总共 360 次测量。退火后的探测器被真空包装在箔片中，然后放置在五位放射化学家和四位护士的双手每个指尖上（一个探测器对应一个指尖）。发现放射化学家和护士的非优势左手受到的电离辐射最大。在 Ga-DOTA-DATE 活性配药过程中，放射化学家的 H(0.07)/A 值最大为 49.36±4.95 mSv/GBq。对于执行放射性药物注射程序的护士，测量到相应的最大值为 1.28±0.13 mSv/GBq，而所有护士的平均值为 0.38 mSv/GBq。配药程序约占放射化学家指尖总暴露量的 60%。根据所得结果，建议常规将戒指剂量计放置在放射化学家和护士的非优势手的中指上。此外，建议有系统地培训工人处理电离辐射源，以减少所需的处理时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/9db2a62fc991/411_2022_1015_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/2ca68fa214a7/411_2022_1015_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/7a99029db56d/411_2022_1015_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/b7bf34967f3b/411_2022_1015_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/e0c9c2ca95a5/411_2022_1015_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/b2156d903e6d/411_2022_1015_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/30ca6141a4cb/411_2022_1015_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/f90b07f9036c/411_2022_1015_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/af270a1293e2/411_2022_1015_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/9db2a62fc991/411_2022_1015_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/2ca68fa214a7/411_2022_1015_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/7a99029db56d/411_2022_1015_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/b7bf34967f3b/411_2022_1015_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/e0c9c2ca95a5/411_2022_1015_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/b2156d903e6d/411_2022_1015_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/30ca6141a4cb/411_2022_1015_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/f90b07f9036c/411_2022_1015_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/af270a1293e2/411_2022_1015_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc2/9950246/9db2a62fc991/411_2022_1015_Fig9_HTML.jpg

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